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Literature DB >> 10639479

MTSA-10, the product of the Rv3874 gene of Mycobacterium tuberculosis, elicits tuberculosis-specific, delayed-type hypersensitivity in guinea pigs.

R Colangeli¹, J S Spencer, P Bifani, A Williams, K Lyashchenko, M A Keen, P J Hill, J Belisle, M L Gennaro.

Abstract

In a search for new skin test reagents specific for tuberculosis, we found that the antigen encoded by gene Rv3874 of Mycobacterium tuberculosis elicited delayed-type hypersensitivity in M. tuberculosis-infected guinea pigs but not in control animals immunized with Mycobacterium bovis bacillus Calmette-Guérin (BCG) or Mycobacterium avium. The antigen, which was named MTSA-10 (for M. tuberculosis-specific antigen 10), is a prime candidate for a component of a new tuberculin that will allow discrimination by a skin test of latent M. tuberculosis infection from vaccination with BCG or from sensitization with environmental, nontuberculous mycobacteria.

Entities: Disease Species

Mesh：

Substances：

Year: 2000 PMID： 10639479 PMCID： PMC97238 DOI： 10.1128/IAI.68.2.990-993.2000

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

23 in total

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Journal: Infect Immun Date: 1997-01 Impact factor: 3.441

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Journal: Infect Immun Date: 1995-10 Impact factor: 3.441

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Journal: Infect Immun Date: 1995-05 Impact factor: 3.441

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Journal: Infect Immun Date: 1996-01 Impact factor: 3.441

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Journal: MMWR Recomm Rep Date: 1995-09-08

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Authors: K M Dobos; K Swiderek; K H Khoo; P J Brennan; J T Belisle
Journal: Infect Immun Date: 1995-08 Impact factor: 3.441

27 in total

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Authors: Marina A Forrellad; Laura I Klepp; Andrea Gioffré; Julia Sabio y García; Hector R Morbidoni; María de la Paz Santangelo; Angel A Cataldi; Fabiana Bigi
Journal: Virulence Date: 2012-10-17 Impact factor: 5.882

4. Enzyme-linked immunospot and tuberculin skin testing to detect latent tuberculosis infection.

Authors: Homayoun Shams; Stephen E Weis; Peter Klucar; Ajit Lalvani; Patrick K Moonan; Janice M Pogoda; Katie Ewer; Peter F Barnes
Journal: Am J Respir Crit Care Med Date: 2005-08-04 Impact factor: 21.405

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Journal: Clin Exp Immunol Date: 2003-10 Impact factor: 4.330

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Authors: Susan L Baldwin; Valerie Reese; Brian Granger; Mark T Orr; Gregory C Ireton; Rhea N Coler; Steven G Reed
Journal: Clin Vaccine Immunol Date: 2014-07-16

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Authors: Raymond L Houghton; Michael J Lodes; Davin C Dillon; Lisa D Reynolds; Craig H Day; Patricia D McNeill; Ronald C Hendrickson; Yasir A W Skeiky; Diana P Sampaio; Roberto Badaro; Konstantin P Lyashchenko; Steven G Reed
Journal: Clin Diagn Lab Immunol Date: 2002-07

9. Human T-cell responses to the RD1-encoded protein TB27.4 (Rv3878) from Mycobacterium tuberculosis.

Authors: Else Marie Agger; Inger Brock; Limei Meng Okkels; Sandra M Arend; Claus S Aagaard; Karin N Weldingh; Peter Andersen
Journal: Immunology Date: 2003-12 Impact factor: 7.397

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Authors: Gavish Kumar; Pradeep Kumar Dagur; Prashant Kumar Singh; Hari Shankar; Virendra S Yadav; Vishwa M Katoch; Bharat Bajaj; Rajesh Gupta; Utpal Sengupta; Beenu Joshi
Journal: Arch Immunol Ther Exp (Warsz) Date: 2010-01-05 Impact factor: 4.291