Literature DB >> 962880

Interaction of pepstatin with pig pepsinogen.

J Kay, C W Dykes.   

Abstract

In contrast with pepsin, pepsinogen does not bind pepstatin at pH values between 5.3 and 2.5. Pepsinogen is not retarded by pepstatin immobilized on to aminohexyl-Sepharose at pH5.3 or 4.1, whereas at pH3.0 activation takes place during the chromatography, with retardation of the resultant pepsin.

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Year:  1976        PMID： 962880      PMCID： PMC1163880          DOI： 10.1042/bj1570499

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  13 in total

1.  An assay to differentiate the "true" activity of pepsin from the potential activity of pepsinogen.

Authors:  J Kay
Journal:  Anal Biochem       Date:  1975-08       Impact factor: 3.365

2.  Conversion of pepsinogen to pepsin. Further evidence for intramolecular and pepsin-catalyzed activation.

Authors:  C G Sanny; J A Hartsuck; J Tang
Journal:  J Biol Chem       Date:  1975-04-10       Impact factor: 5.157

3.  Interaction of human cathepsin D with the inhibitor pepstatin.

Authors:  C G Knight; A J Barrett
Journal:  Biochem J       Date:  1976-04-01       Impact factor: 3.857

4.  Mechanism of inhibition of pepsin by pepstatin. II.

Authors:  S Kunimoto; T Aoyagi; R Nishizawa; T Komai; T Takeuchi
Journal:  J Antibiot (Tokyo)       Date:  1974-06       Impact factor: 2.649

5.  The activation of bovine pepsinogen. Sequence of the peptides released, identification of a pepsin inhibitor.

Authors:  M Harboe; P M Andersen; B Foltmann; J Kay; B Kassell
Journal:  J Biol Chem       Date:  1974-07-25       Impact factor: 5.157

6.  A spectrophotometric investigation of the pepsinogen-pepsin conversion.

Authors:  P McPhie
Journal:  J Biol Chem       Date:  1972-07-10       Impact factor: 5.157

7.  Kinetics and mechanism of pepsinogen activation.

Authors:  J al-Janabi; J A Hartsuck; J Tang
Journal:  J Biol Chem       Date:  1972-07-25       Impact factor: 5.157

8.  Affinity chromatographic differentiation of lactate dehydrogenase isoenzymes on the basis of differential abortive complex formation.

Authors:  P O'Carra; S Barry; E Corcoran
Journal:  FEBS Lett       Date:  1974-07-15       Impact factor: 4.124

9.  Conversion of pepsinogen into pepsin is not a one-step process.

Authors:  C W Dykes; J Kay
Journal:  Biochem J       Date:  1976-01-01       Impact factor: 3.857

10.  Effect of pepstatin on acid proteases.

Authors:  T Aoyagi; S Kunimoto; H Morishima; T Takeuchi; H Umezawa
Journal:  J Antibiot (Tokyo)       Date:  1971-10       Impact factor: 2.649
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  1 in total

1.  The first step in the activation of chicken pepsinogen is similar to that of prochymosin.

Authors:  H Keilova; V Kostka; J Kay
Journal:  Biochem J       Date:  1977-12-01       Impact factor: 3.857
  1 in total

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