Literature DB >> 960726

Preferential inhibition of herpes-group viruses by phosphonoacetic acid: effect on virus DNA synthesis and virus-induced DNA polymerase activity.

E S Huang, C H Huang, S M Huong, M Selgrade.   

Abstract

In tissue culture phosphonoacetic acid (PAA) specifically inhibited DNA synthesis of human cytomegalovirus (CMV), murine CMV, simian CMV, Epstein-Barr virus, and Herpesvirus saimiri. Fifty to one hundred micrograms per milliliter PAA completely inhibited viral DNA synthesis with no significant damage to host cell DNA synthesis. In vitro DNA polymerization assays showed that 10 μg/ml of PAA specifically inhibited partially purified human CMV-induced DNA polymerase, while little inhibition of host-cell DNA polymerase activity was found. The specific inhibition of herpes-group virus DNA synthesis with little toxicity to host cells suggests that PAA has great potential as an antiherpesvirus therapeutic agent.

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Year:  1976        PMID： 960726      PMCID： PMC2595326     

Source DB:  PubMed          Journal:  Yale J Biol Med        ISSN： 0044-0086


  11 in total

1.  Inhibition of herpes simplex virus replication by phosphonoacetic acid.

Authors:  L R Overby; E E Robishaw; J B Schleicher; A Rueter; N L Shipkowitz; J C Mao
Journal:  Antimicrob Agents Chemother       Date:  1974-09       Impact factor: 5.191

2.  Human cytomegalovirus. III. Virus-induced DNA polymerase.

Authors:  E S Huang
Journal:  J Virol       Date:  1975-08       Impact factor: 5.103

3.  Herpesviruses saimiri and ateles--their role in malignant lymphomas of monkeys.

Authors:  L V Melèndez; R D Hunt; M D Daniel; C E Fraser; H H Barahona; N W King; F G Garcìa
Journal:  Fed Proc       Date:  1972 Nov-Dec

4.  Detection of Epstein-Barr viral genome in nonproductive cells.

Authors:  M Nonoyama; J S Pagano
Journal:  Nat New Biol       Date:  1971-09-22

5.  Human cytomegalovirus. I. Purification and characterization of viral DNA.

Authors:  E S Huang; S T Chen; J S Pagano
Journal:  J Virol       Date:  1973-12       Impact factor: 5.103

6.  Spectrum of human cytomegalovirus complement-fixing antigens.

Authors:  G R Dreesman; M Benyesh-Melnick
Journal:  J Immunol       Date:  1967-12       Impact factor: 5.422

7.  Human cytomegalovirus. IV. Specific inhibition of virus-induced DNA polymerase activity and viral DNA replication by phosphonoacetic acid.

Authors:  E S Huang
Journal:  J Virol       Date:  1975-12       Impact factor: 5.103

8.  Suppression of herpes simplex virus infection by phosphonoacetic acid.

Authors:  N L Shipkowitz; R R Bower; R N Appell; C W Nordeen; L R Overby; W R Roderick; J B Schleicher; A M Von Esch
Journal:  Appl Microbiol       Date:  1973-09

9.  Growth of murine cytomegalovirus in various cell lines.

Authors:  K S Kim; R I Carp
Journal:  J Virol       Date:  1971-06       Impact factor: 5.103

10.  Detection of human cytomegalovirus and analysis of strain variation.

Authors:  E S Huang; B A Kilpatrick; Y T Huang; J S Pagano
Journal:  Yale J Biol Med       Date:  1976-03
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  10 in total

1.  Cytofluorometry of lymphocytes infected with Epstein-Barr virus: effect of phosphonoacetic acid on nucleic acid.

Authors:  S M Lemon; L M Hutt; J S Pagano
Journal:  J Virol       Date:  1978-01       Impact factor: 5.103

2.  Suppression of TLR9 immunostimulatory motifs in the genome of a gammaherpesvirus.

Authors:  Andrea C Pezda; Alex Penn; Gregory M Barton; Laurent Coscoy
Journal:  J Immunol       Date:  2011-06-10       Impact factor: 5.422

3.  Epstein-Barr virus transformation of human B lymphocytes despite inhibition of viral polymerase.

Authors:  J W Sixbey; J S Pagano
Journal:  J Virol       Date:  1985-01       Impact factor: 5.103

4.  Complex expression of the UL136 gene of human cytomegalovirus results in multiple protein isoforms with unique roles in replication.

Authors:  Katie Caviness; Louis Cicchini; Michael Rak; Mahadevaiah Umashankar; Felicia Goodrum
Journal:  J Virol       Date:  2014-10-08       Impact factor: 5.103

5.  Compounds that target host cell proteins prevent varicella-zoster virus replication in culture, ex vivo, and in SCID-Hu mice.

Authors:  Jenny Rowe; Rebecca J Greenblatt; Dongmei Liu; Jennifer F Moffat
Journal:  Antiviral Res       Date:  2010-03-20       Impact factor: 5.970

6.  Immune response and latent infection after topical treatment of herpes simplex virus infection in hairless mice.

Authors:  R J Klein; A E Friedman-Kien; A A Fondak; E Buimovici-Klein
Journal:  Infect Immun       Date:  1977-06       Impact factor: 3.441

7.  Synthesis of Epstein-Barr virus DNA in vitro: effects of phosphonoacetic acid, N-ethylmaleimide, and ATP.

Authors:  T Seebeck; J E Shaw; J S Pagano
Journal:  J Virol       Date:  1977-01       Impact factor: 5.103

8.  Murine cytomegalovirus protein pM92 is a conserved regulator of viral late gene expression.

Authors:  Travis J Chapa; Yi-Cheih Perng; Anthony R French; Dong Yu
Journal:  J Virol       Date:  2013-10-16       Impact factor: 5.103

9.  Quantitative membrane proteomics reveals a role for tetraspanin enriched microdomains during entry of human cytomegalovirus.

Authors:  Kasinath Viswanathan; Marieke C Verweij; Nessy John; Daniel Malouli; Klaus Früh
Journal:  PLoS One       Date:  2017-11-09       Impact factor: 3.240

10.  Advances in Model Systems for Human Cytomegalovirus Latency and Reactivation.

Authors:  Lindsey B Crawford; Nicole L Diggins; Patrizia Caposio; Meaghan H Hancock
Journal:  mBio       Date:  2022-01-11       Impact factor: 7.867
  10 in total

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