Literature DB >> 2981351

Epstein-Barr virus transformation of human B lymphocytes despite inhibition of viral polymerase.

J W Sixbey, J S Pagano.   

Abstract

Epstein-Barr virus transformed human lymphocytes despite the presence of up to 500 microM acyclovir [9-(2-hydroxyethoxymethyl)guanine], a viral DNA polymerase inhibitor. The transformed cells contained multiple Epstein-Barr virus genome copy numbers. Functional viral DNA polymerase is probably not required for cell transformation and the initial amplification of the viral genome.

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Year:  1985        PMID： 2981351      PMCID： PMC255037     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  18 in total

1.  Studies of an Epstein-Barr virus-induced DNA polymerase.

Authors:  R L Miller; R Glaser; F Rapp
Journal:  Virology       Date:  1977-02       Impact factor: 3.616

2.  Diseases and mechanisms of persistent DNA virus infection: latency and cellular transformation.

Authors:  J S Pagano
Journal:  J Infect Dis       Date:  1975-08       Impact factor: 5.226

3.  Cytofluorometry of lymphocytes infected with Epstein-Barr virus: effect of phosphonoacetic acid on nucleic acid.

Authors:  S M Lemon; L M Hutt; J S Pagano
Journal:  J Virol       Date:  1978-01       Impact factor: 5.103

4.  Transformation of human lymphocytes by Epstein-Barr virus is inhibited by phosphonoacetic acid.

Authors:  D Thorley-Lawson; J L Strominger
Journal:  Nature       Date:  1976-09-23       Impact factor: 49.962

5.  Efficiency of transformation of lymphocytes by Epstein-Barr virus.

Authors:  E Henderson; G Miller; J Robinson; L Heston
Journal:  Virology       Date:  1977-01       Impact factor: 3.616

6.  Reversible inhibition by phosphonoacetic acid of human B lymphocyte transformation by Epstein-Barr virus.

Authors:  D A Thorley-Lawson; J L Strominger
Journal:  Virology       Date:  1978-05-15       Impact factor: 3.616

7.  Detection of Epstein-Barr viral genome in nonproductive cells.

Authors:  M Nonoyama; J S Pagano
Journal:  Nat New Biol       Date:  1971-09-22

8.  Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

Authors:  A Böyum
Journal:  Scand J Clin Lab Invest Suppl       Date:  1968

9.  Effect of acyclovir [9-(2-hydroxyethoxymethyl)guanine] on Epstein-Barr virus DNA replication.

Authors:  B M Colby; J E Shaw; G B Elion; J S Pagano
Journal:  J Virol       Date:  1980-05       Impact factor: 5.103

10.  Preferential inhibition of herpes-group viruses by phosphonoacetic acid: effect on virus DNA synthesis and virus-induced DNA polymerase activity.

Authors:  E S Huang; C H Huang; S M Huong; M Selgrade
Journal:  Yale J Biol Med       Date:  1976-03
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  5 in total

1.  Epstein-Barr virus-derived plasmids replicate only once per cell cycle and are not amplified after entry into cells.

Authors:  J L Yates; N Guan
Journal:  J Virol       Date:  1991-01       Impact factor: 5.103

2.  Relative rates of RNA synthesis across the genome of Epstein-Barr virus are highest near oriP and oriLyt.

Authors:  S Metzenberg
Journal:  J Virol       Date:  1989-11       Impact factor: 5.103

3.  Screening for Epstein-Barr and human cytomegalovirus in normal and abnormal cervical smears by fluorescent in situ cytohybridization.

Authors:  H J Schön; B Schurz; R Marz; W Knogler; E Kubista
Journal:  Arch Virol       Date:  1992       Impact factor: 2.574

4.  Herpesvirus sylvilagus infects both B and T lymphocytes in vivo.

Authors:  W J Kramp; P Medveczky; C Mulder; H C Hinze; J L Sullivan
Journal:  J Virol       Date:  1985-10       Impact factor: 5.103

Review 5.  The antiviral prophylaxis of post-transplant lymphoproliferative disorder.

Authors:  C L Davis
Journal:  Springer Semin Immunopathol       Date:  1998
  5 in total

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