| Literature DB >> 958038 |
Abstract
This communication advances the proposal that all the diverse manifestations of scurvy can be attributed to depolymerisation of ground substance glycosaminoglycans brought about by exposure to uninhibited cellular hyaluronidase. It suggests that ascorbic acid exerts its prime biological function indirectly by incorporation into a glycosaminoglycan residue to form the physiological hyaluronidase inhibitor. The therapeutic implications of this working hypothesis are briefly discussed.Entities:
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Year: 1976 PMID： 958038 DOI： 10.1016/0306-9877(76)90072-4
Source DB: PubMed Journal: Med Hypotheses ISSN： 0306-9877 Impact factor: 1.538