Literature DB >> 9573303

Human immunodeficiency virus type 2 Vpx-Gag interaction.

H A Pancio1, L Ratner.   

Abstract

Incorporation of Vpx into human immunodeficiency virus type 2 (HIV-2) virus-like particles is mediated by the Gag polyprotein. We have identified residues 15 to 40 of Gag p6 and residues 73 to 89 of Vpx as being necessary for virion incorporation. In addition, we show enhanced in vitro binding of Vpx to a chimeric HIV-1/HIV-2 Gag construct containing residues 2 to 49 of HIV-2 p6 and demonstrate that the presence of residues 73 to 89 of Vpx allows for in vitro binding to HIV-2 Gag.

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Year:  1998        PMID： 9573303      PMCID： PMC110118          DOI： 10.1128/JVI.72.6.5271-5275.1998

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  24 in total

1.  The human immunodeficiency virus type 2 (HIV-2) contains a novel gene encoding a 16 kD protein associated with mature virions.

Authors:  G Franchini; J R Rusche; T J O'Keeffe; F Wong-Staal
Journal:  AIDS Res Hum Retroviruses       Date:  1988-08       Impact factor: 2.205

2.  Genome organization and transactivation of the human immunodeficiency virus type 2.

Authors:  M Guyader; M Emerman; P Sonigo; F Clavel; L Montagnier; M Alizon
Journal:  Nature       Date:  1987 Apr 16-22       Impact factor: 49.962

3.  Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase.

Authors:  D B Smith; K S Johnson
Journal:  Gene       Date:  1988-07-15       Impact factor: 3.688

4.  Dispensable role of the human immunodeficiency virus type 2 Vpx protein in viral replication.

Authors:  L Marcon; F Michaels; N Hattori; K Fargnoli; R C Gallo; G Franchini
Journal:  J Virol       Date:  1991-07       Impact factor: 5.103

5.  Human immunodeficiency virus type 2 vpx protein augments viral infectivity.

Authors:  J C Kappes; J A Conway; S W Lee; G M Shaw; B H Hahn
Journal:  Virology       Date:  1991-09       Impact factor: 3.616

6.  Nuclear import and cell cycle arrest functions of the HIV-1 Vpr protein are encoded by two separate genes in HIV-2/SIV(SM).

Authors:  T M Fletcher; B Brichacek; N Sharova; M A Newman; G Stivahtis; P M Sharp; M Emerman; B H Hahn; M Stevenson
Journal:  EMBO J       Date:  1996-11-15       Impact factor: 11.598

7.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

8.  Isolation and characterization of a novel protein (X-ORF product) from SIV and HIV-2.

Authors:  L E Henderson; R C Sowder; T D Copeland; R E Benveniste; S Oroszlan
Journal:  Science       Date:  1988-07-08       Impact factor: 47.728

9.  Sequence of simian immunodeficiency virus from macaque and its relationship to other human and simian retroviruses.

Authors:  L Chakrabarti; M Guyader; M Alizon; M D Daniel; R C Desrosiers; P Tiollais; P Sonigo
Journal:  Nature       Date:  1987 Aug 6-12       Impact factor: 49.962

10.  VPX mutants of HIV-2 are infectious in established cell lines but display a severe defect in peripheral blood lymphocytes.

Authors:  M Guyader; M Emerman; L Montagnier; K Peden
Journal:  EMBO J       Date:  1989-04       Impact factor: 11.598
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  12 in total

1.  Interaction of human immunodeficiency virus type 2 Vpx and invariant chain.

Authors:  H A Pancio; N Vander Heyden; K Kosuri; P Cresswell; L Ratner
Journal:  J Virol       Date:  2000-07       Impact factor: 5.103

2.  The C-terminal proline-rich tail of human immunodeficiency virus type 2 Vpx is necessary for nuclear localization of the viral preintegration complex in nondividing cells.

Authors:  H A Pancio; N Vander Heyden; L Ratner
Journal:  J Virol       Date:  2000-07       Impact factor: 5.103

3.  Vif is largely absent from human immunodeficiency virus type 1 mature virions and associates mainly with viral particles containing unprocessed gag.

Authors:  P Sova; D J Volsky; L Wang; W Chao
Journal:  J Virol       Date:  2001-06       Impact factor: 5.103

4.  Hsp40 facilitates nuclear import of the human immunodeficiency virus type 2 Vpx-mediated preintegration complex.

Authors:  Xiaogang Cheng; Michael Belshan; Lee Ratner
Journal:  J Virol       Date:  2007-11-21       Impact factor: 5.103

Review 5.  HIV Genome-Wide Protein Associations: a Review of 30 Years of Research.

Authors:  Guangdi Li; Erik De Clercq
Journal:  Microbiol Mol Biol Rev       Date:  2016-06-29       Impact factor: 11.056

6.  A conserved dileucine-containing motif in p6(gag) governs the particle association of Vpx and Vpr of simian immunodeficiency viruses SIV(mac) and SIV(agm).

Authors:  M A Accola; A A Bukovsky; M S Jones; H G Göttlinger
Journal:  J Virol       Date:  1999-12       Impact factor: 5.103

7.  Functional analysis of the simian immunodeficiency virus Vpx protein: identification of packaging determinants and a novel nuclear targeting domain.

Authors:  S Mahalingam; B Van Tine; M L Santiago; F Gao; G M Shaw; B H Hahn
Journal:  J Virol       Date:  2001-01       Impact factor: 5.103

8.  Interaction with the p6 domain of the gag precursor mediates incorporation into virions of Vpr and Vpx proteins from primate lentiviruses.

Authors:  L Selig; J C Pages; V Tanchou; S Prévéral; C Berlioz-Torrent; L X Liu; L Erdtmann; J Darlix; R Benarous; S Benichou
Journal:  J Virol       Date:  1999-01       Impact factor: 5.103

9.  A cellular restriction dictates the permissivity of nondividing monocytes/macrophages to lentivirus and gammaretrovirus infection.

Authors:  Rajnish Kaushik; Xiaonan Zhu; Ruzena Stranska; Yuanfei Wu; Mario Stevenson
Journal:  Cell Host Microbe       Date:  2009-07-23       Impact factor: 21.023

10.  HIV-2 Vpx protein interacts with interferon regulatory factor 5 (IRF5) and inhibits its function.

Authors:  Xiaogang Cheng; Lee Ratner
Journal:  J Biol Chem       Date:  2014-02-14       Impact factor: 5.157
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