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Literature DB >> 9536845

In vitro effect of dexamethasone phosphate on hematopoietic progenitor cells in preterm infants.

P Papoff¹, R D Christensen, J Harcum, Y Li.

Abstract

The in vitro effect of dexamethasone on the clonal growth of haematopoietic progenitors in preterm infants was investigated. Concentrations of 10(6)M to 10(9)M were associated with a dose dependent inhibition of colony formation, with the most clinically important effects seen on the earliest erythroid and granulocyte-macrophage colonies. Because of the potential clinical implications of these observations, studies are needed to determine the effects of dexamethasone on haematopoiesis in preterm infants.

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Year: 1998 PMID： 9536845 PMCID： PMC1720743 DOI： 10.1136/fn.78.1.f67

Source DB: PubMed Journal: Arch Dis Child Fetal Neonatal Ed ISSN： 1359-2998 Impact factor: 5.747

12 in total

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Authors: S M Rhondeau; R D Christensen; M P Ross; G Rothstein; M A Simmons
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In vitro effect of dexamethasone phosphate on hematopoietic progenitor cells in preterm infants.

Review 1. Anti-inflammatory mechanisms of glucocorticoids.

Review 2. [CD34+ cells: biological aspects].

3. Inhibition of murine granulopoiesis in vitro by dexamethasone.

4. Glucocorticoids and interferon-alpha in the acquired immunodeficiency syndrome.

5. Pharmacokinetics of dexamethasone in premature neonates.

6. Responsiveness to recombinant human erythropoietin of marrow erythroid progenitors from infants with the "anemia of prematurity".

Review 7. Glucocorticosteroid action on the immune system: molecular and cellular aspects.

8. Glucocorticoid receptor in chick erythrocytes.

9. Effects of dexamethasone on erythroid colony and burst formation from human fetal liver and adult marrow.

10. Differential response of early erythropoietic and granulopoietic progenitors to dexamethasone and cortisone.

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