OBJECTIVE: Dexamethasone is frequently used in premature neonates with bronchopulmonary dysplasia, however little is known about its disposition in this population. METHODS: We evaluated the pharmacokinetics of dexamethasone in 9 premature neonates with a mean gestational age of 27.3 weeks and a postnatal age of 21.8 days. RESULTS: There was a strong relationship between clearance (4.96 ml.min-1.kg-1) and gestational age ( r = 0.884). Pharmacokinetic parameters were grouped based on a gestational age of less than 27 weeks (Group I) and greater than 27 weeks (Group II). Mean clearance in group I and group II was 1.69 and 7,57 ml.min-1.kg-1, respectively. Mean distribution volume in group I and II was 1.26 and 2.19 l.kg-1, respectively. No significant relationships were noted between the disposition of dexamethasone and ventilator requirements or adverse effects. CONCLUSION: The pharmacokinetics of dexamethasone in premature neonates was related to gestational age.
OBJECTIVE:Dexamethasone is frequently used in premature neonates with bronchopulmonary dysplasia, however little is known about its disposition in this population. METHODS: We evaluated the pharmacokinetics of dexamethasone in 9 premature neonates with a mean gestational age of 27.3 weeks and a postnatal age of 21.8 days. RESULTS: There was a strong relationship between clearance (4.96 ml.min-1.kg-1) and gestational age ( r = 0.884). Pharmacokinetic parameters were grouped based on a gestational age of less than 27 weeks (Group I) and greater than 27 weeks (Group II). Mean clearance in group I and group II was 1.69 and 7,57 ml.min-1.kg-1, respectively. Mean distribution volume in group I and II was 1.26 and 2.19 l.kg-1, respectively. No significant relationships were noted between the disposition of dexamethasone and ventilator requirements or adverse effects. CONCLUSION: The pharmacokinetics of dexamethasone in premature neonates was related to gestational age.
Authors: Ann R Stark; Waldemar A Carlo; Betty R Vohr; Lu Ann Papile; Shampa Saha; Charles R Bauer; William Oh; Seetha Shankaran; Jon E Tyson; Linda L Wright; W Kenneth Poole; Abhik Das; Barbara J Stoll; Avroy A Fanaroff; Sheldon B Korones; Richard A Ehrenkranz; David K Stevenson; Myriam Peralta-Carcelen; Deanne E Wilson-Costello; Henrietta S Bada; Roy J Heyne; Yvette R Johnson; Kimberly Gronsman Lee; Jean J Steichen Journal: J Pediatr Date: 2013-08-27 Impact factor: 4.406
Authors: Dennis Davidson; Hardik Patel; Ana C Degoy; Irina Gershkovich; Ivana Vancurova; Veronika Miskolci Journal: Am J Transl Res Date: 2013-01-21 Impact factor: 4.060
Authors: Esther M Speer; David J Dowling; Jianjin Xu; Lukasz S Ozog; Jaime A Mathew; Avinash Chander; Donglei Yin; Ofer Levy Journal: PLoS One Date: 2018-05-01 Impact factor: 3.240