Literature DB >> 9527814

QacA multidrug efflux pump from Staphylococcus aureus: comparative analysis of resistance to diamidines, biguanidines, and guanylhydrazones.

B A Mitchell1, M H Brown, R A Skurray.   

Abstract

The staphylococcal multidrug efflux pump QacA mediates resistance to a broad spectrum of monovalent and divalent antimicrobial cations. Resistance toward various classes of these compounds identified features of the substrate that may be important for interaction with QacA. Analysis of combinations of two substrates suggested that the same mechanism is used for the extrusion of different classes of compounds.

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Year:  1998        PMID： 9527814      PMCID： PMC105442          DOI： 10.1128/AAC.42.2.475

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Efflux-mediated antiseptic resistance gene qacA from Staphylococcus aureus: common ancestry with tetracycline- and sugar-transport proteins.

Authors:  D A Rouch; D S Cram; D DiBerardino; T G Littlejohn; R A Skurray
Journal:  Mol Microbiol       Date:  1990-12       Impact factor: 3.501

2.  In vitro packaging of lambda and cosmid DNA.

Authors:  B Hohn
Journal:  Methods Enzymol       Date:  1979       Impact factor: 1.600

Review 3.  Proton-dependent multidrug efflux systems.

Authors:  I T Paulsen; M H Brown; R A Skurray
Journal:  Microbiol Rev       Date:  1996-12

4.  Multidrug resistance proteins QacA and QacB from Staphylococcus aureus: membrane topology and identification of residues involved in substrate specificity.

Authors:  I T Paulsen; M H Brown; T G Littlejohn; B A Mitchell; R A Skurray
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-16       Impact factor: 11.205

5.  Guanylhydrazones in therapy of Pneumocystis carinii pneumonia in immunosuppressed rats.

Authors:  P D Walzer; J Foy; J Runck; P Steele; M White; R S Klein; B A Otter; R J Sundberg
Journal:  Antimicrob Agents Chemother       Date:  1994-11       Impact factor: 5.191

6.  Substrate specificity and energetics of antiseptic and disinfectant resistance in Staphylococcus aureus.

Authors:  T G Littlejohn; I T Paulsen; M T Gillespie; J M Tennent; M Midgley; I G Jones; A S Purewal; R A Skurray
Journal:  FEMS Microbiol Lett       Date:  1992-08-15       Impact factor: 2.742

Review 7.  A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport.

Authors:  M D Marger; M H Saier
Journal:  Trends Biochem Sci       Date:  1993-01       Impact factor: 13.807

8.  Physical and biochemical characterization of the qacA gene encoding antiseptic and disinfectant resistance in Staphylococcus aureus.

Authors:  J M Tennent; B R Lyon; M Midgley; I G Jones; A S Purewal; R A Skurray
Journal:  J Gen Microbiol       Date:  1989-01

9.  In vitro activities of metronidazole and its hydroxy metabolite against Bacteroides spp.

Authors:  S L Pendland; S C Piscitelli; P C Schreckenberger; L H Danziger
Journal:  Antimicrob Agents Chemother       Date:  1994-09       Impact factor: 5.191
  9 in total
  29 in total

1.  The TetA(K) tetracycline/H(+) antiporter from Staphylococcus aureus: mutagenesis and functional analysis of motif C.

Authors:  S L Ginn; M H Brown; R A Skurray
Journal:  J Bacteriol       Date:  2000-03       Impact factor: 3.490

Review 2.  Potential impact of increased use of biocides in consumer products on prevalence of antibiotic resistance.

Authors:  Peter Gilbert; Andrew J McBain
Journal:  Clin Microbiol Rev       Date:  2003-04       Impact factor: 26.132

3.  Low-level resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein 1 in vitro associated with qacA gene carriage is independent of multidrug efflux pump activity.

Authors:  A S Bayer; L I Kupferwasser; M H Brown; R A Skurray; S Grkovic; T Jones; K Mukhopadhay; M R Yeaman
Journal:  Antimicrob Agents Chemother       Date:  2006-07       Impact factor: 5.191

4.  Plasmid-mediated resistance to thrombin-induced platelet microbicidal protein in staphylococci: role of the qacA locus.

Authors:  L I Kupferwasser; R A Skurray; M H Brown; N Firth; M R Yeaman; A S Bayer
Journal:  Antimicrob Agents Chemother       Date:  1999-10       Impact factor: 5.191

5.  Action of disinfectant quaternary ammonium compounds against Staphylococcus aureus.

Authors:  Christopher J Ioannou; Geoff W Hanlon; Stephen P Denyer
Journal:  Antimicrob Agents Chemother       Date:  2006-10-23       Impact factor: 5.191

6.  MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus.

Authors:  Q C Truong-Bolduc; P M Dunman; J Strahilevitz; S J Projan; D C Hooper
Journal:  J Bacteriol       Date:  2005-04       Impact factor: 3.490

Review 7.  Multidrug efflux pumps in Staphylococcus aureus and their clinical implications.

Authors:  Soojin Jang
Journal:  J Microbiol       Date:  2016-01-05       Impact factor: 3.422

8.  Investigation of ligand binding to the multidrug resistance protein EmrE by isothermal titration calorimetry.

Authors:  Curtis W Sikora; Raymond J Turner
Journal:  Biophys J       Date:  2004-10-22       Impact factor: 4.033

9.  Efflux Pumps Might Not Be the Major Drivers of QAC Resistance in Methicillin-Resistant Staphylococcus aureus.

Authors:  Megan C Jennings; Megan E Forman; Stephanie M Duggan; Kevin P C Minbiole; William M Wuest
Journal:  Chembiochem       Date:  2017-06-27       Impact factor: 3.164

10.  High rate of qacA- and qacB-positive methicillin-resistant Staphylococcus aureus isolates from chlorhexidine-impregnated catheter-related bloodstream infections.

Authors:  Cheng-Mao Ho; Chi-Yuan Li; Mao-Wang Ho; Chien-Yu Lin; Shu-Hui Liu; Jang-Jih Lu
Journal:  Antimicrob Agents Chemother       Date:  2012-08-20       Impact factor: 5.191
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