Literature DB >> 1526458

Substrate specificity and energetics of antiseptic and disinfectant resistance in Staphylococcus aureus.

T G Littlejohn1, I T Paulsen, M T Gillespie, J M Tennent, M Midgley, I G Jones, A S Purewal, R A Skurray.   

Abstract

Clinical isolates of Staphylococcus aureus carry various antiseptic and disinfectant resistance determinants (qac genes) on a variety of plasmids. The biochemistry and specificity of these resistance genes in S. aureus is the subject of this report. The qac genes were separated into two families on the basis of resistance profiles and DNA homology. Isotopic and fluorimetric assays demonstrated that the qac genes encode efflux systems that rely on proton motive force.

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Year:  1992        PMID： 1526458     DOI： 10.1016/0378-1097(92)90439-u

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  53 in total

1.  Low sensitivity of Listeria monocytogenes to quaternary ammonium compounds.

Authors:  L Mereghetti; R Quentin; N Marquet-Van Der Mee; A Audurier
Journal:  Appl Environ Microbiol       Date:  2000-11       Impact factor: 4.792

Review 2.  Molecular properties of bacterial multidrug transporters.

Authors:  M Putman; H W van Veen; W N Konings
Journal:  Microbiol Mol Biol Rev       Date:  2000-12       Impact factor: 11.056

3.  The staphylococcal QacR multidrug regulator binds a correctly spaced operator as a pair of dimers.

Authors:  S Grkovic; M H Brown; M A Schumacher; R G Brennan; R A Skurray
Journal:  J Bacteriol       Date:  2001-12       Impact factor: 3.490

4.  Membrane topology of the multidrug transporter MdfA: complementary gene fusion studies reveal a nonessential C-terminal domain.

Authors:  Julia Adler; Eitan Bibi
Journal:  J Bacteriol       Date:  2002-06       Impact factor: 3.490

Review 5.  Potential impact of increased use of biocides in consumer products on prevalence of antibiotic resistance.

Authors:  Peter Gilbert; Andrew J McBain
Journal:  Clin Microbiol Rev       Date:  2003-04       Impact factor: 26.132

6.  Antimicrobial agent of susceptibilities and antiseptic resistance gene distribution among methicillin-resistant Staphylococcus aureus isolates from patients with impetigo and staphylococcal scalded skin syndrome.

Authors:  Norihisa Noguchi; Hidemasa Nakaminami; Setsuko Nishijima; Ichiro Kurokawa; Hiromu So; Masanori Sasatsu
Journal:  J Clin Microbiol       Date:  2006-06       Impact factor: 5.948

7.  Characterization of the earliest known Staphylococcus aureus plasmid encoding a multidrug efflux system.

Authors:  I T Paulsen; M H Brown; R A Skurray
Journal:  J Bacteriol       Date:  1998-07       Impact factor: 3.490

Review 8.  Xenobiotic efflux in bacteria and fungi: a genomics update.

Authors:  Ravi D Barabote; Jose Thekkiniath; Richard E Strauss; Govindsamy Vediyappan; Joe A Fralick; Michael J San Francisco
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  2011

9.  The 3' conserved segment of integrons contains a gene associated with multidrug resistance to antiseptics and disinfectants.

Authors:  I T Paulsen; T G Littlejohn; P Rådström; L Sundström; O Sköld; G Swedberg; R A Skurray
Journal:  Antimicrob Agents Chemother       Date:  1993-04       Impact factor: 5.191

10.  Molecular characterization of the staphylococcal multidrug resistance export protein QacC.

Authors:  I T Paulsen; M H Brown; S J Dunstan; R A Skurray
Journal:  J Bacteriol       Date:  1995-05       Impact factor: 3.490
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