Literature DB >> 26727895

Multidrug efflux pumps in Staphylococcus aureus and their clinical implications.

Soojin Jang1.   

Abstract

Antibiotic resistance is rapidly spreading among bacteria such as Staphylococcus aureus, an opportunistic bacterial pathogen that causes a variety of diseases in humans. For the last two decades, bacterial multidrug efflux pumps have drawn attention due to their potential association with clinical multidrug resistance. Numerous researchers have demonstrated efflux-mediated resistance in vitro and in vivo and found novel multidrug transporters using advanced genomic information about bacteria. This article aims to provide a concise summary of multidrug efflux pumps and their important clinical implications, focusing on recent findings concerning S. aureus efflux pumps.

Entities:  

Keywords:  MRSA; Staphylococcus aureus; multidrug efflux pumps; multidrug resistance

Mesh：

Substances：

Year:  2016        PMID： 26727895     DOI： 10.1007/s12275-016-5159-z

Source DB:  PubMed          Journal:  J Microbiol        ISSN： 1225-8873            Impact factor:   3.422


  99 in total

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Authors:  Victoria G Lewis; Miranda P Ween; Christopher A McDevitt
Journal:  Protoplasma       Date:  2012-01-13       Impact factor: 3.356

2.  MepR, a repressor of the Staphylococcus aureus MATE family multidrug efflux pump MepA, is a substrate-responsive regulatory protein.

Authors:  Glenn W Kaatz; Carmen E DeMarco; Susan M Seo
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Review 3.  Co-resistance: an opportunity for the bacteria and resistance genes.

Authors:  Rafael Cantón; Patricia Ruiz-Garbajosa
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4.  Mutations within the mepA operator affect binding of the MepR regulatory protein and its induction by MepA substrates in Staphylococcus aureus.

Authors:  Bryan D Schindler; Susan M Seo; Ivan Birukou; Richard G Brennan; Glenn W Kaatz
Journal:  J Bacteriol       Date:  2015-01-12       Impact factor: 3.490

Review 5.  Antibiotic resistance in staphylococci.

Authors:  D M Livermore
Journal:  Int J Antimicrob Agents       Date:  2000-11       Impact factor: 5.283

6.  Clonal relatedness is a predictor of spontaneous multidrug efflux pump gene overexpression in Staphylococcus aureus.

Authors:  Bryan D Schindler; Pauline L Jacinto; Joseph Adrian L Buensalido; Susan M Seo; Glenn W Kaatz
Journal:  Int J Antimicrob Agents       Date:  2014-12-10       Impact factor: 5.283

7.  Phenothiazines and thioxanthenes inhibit multidrug efflux pump activity in Staphylococcus aureus.

Authors:  Glenn W Kaatz; Varsha V Moudgal; Susan M Seo; Jette E Kristiansen
Journal:  Antimicrob Agents Chemother       Date:  2003-02       Impact factor: 5.191

8.  Drug efflux pump deficiency and drug target resistance masking in growing bacteria.

Authors:  David Fange; Karin Nilsson; Tanel Tenson; Måns Ehrenberg
Journal:  Proc Natl Acad Sci U S A       Date:  2009-05-01       Impact factor: 11.205

9.  Inhibition of multidrug efflux as a strategy to prevent biofilm formation.

Authors:  Stephanie Baugh; Charlotte R Phillips; Aruna S Ekanayaka; Laura J V Piddock; Mark A Webber
Journal:  J Antimicrob Chemother       Date:  2013-10-31       Impact factor: 5.790

10.  Significant Differences Characterise the Correlation Coefficients between Biocide and Antibiotic Susceptibility Profiles in Staphylococcus aureus.

Authors:  Marco R Oggioni; Joana Rosado Coelho; Leonardo Furi; Daniel R Knight; Carlo Viti; Graziella Orefici; Jose-Luis Martinez; Ana Teresa Freitas; Teresa M Coque; Ian Morrissey
Journal:  Curr Pharm Des       Date:  2015       Impact factor: 3.116
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  23 in total

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Journal:  J Antimicrob Chemother       Date:  2018-03-01       Impact factor: 5.790

2.  Modulation of Staphylococcus aureus Response to Antimicrobials by the Candida albicans Quorum Sensing Molecule Farnesol.

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3.  Antibacterial Activity of Hexadecynoic Acid Isomers toward Clinical Isolates of Multidrug-Resistant Staphylococcus aureus.

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Journal:  Lipids       Date:  2020-01-24       Impact factor: 1.880

4.  Efficacy of Cordyceps militaris Extracts against Some Skin Pathogenic Bacteria and Antioxidant Activity.

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Review 5.  Multidrug Efflux Pumps at the Crossroad between Antibiotic Resistance and Bacterial Virulence.

Authors:  Manuel Alcalde-Rico; Sara Hernando-Amado; Paula Blanco; José L Martínez
Journal:  Front Microbiol       Date:  2016-09-21       Impact factor: 5.640

6.  Eradication and Sensitization of Methicillin Resistant Staphylococcus aureus to Methicillin with Bioactive Extracts of Berry Pomace.

Authors:  Serajus Salaheen; Mengfei Peng; Jungsoo Joo; Hironori Teramoto; Debabrata Biswas
Journal:  Front Microbiol       Date:  2017-02-21       Impact factor: 5.640

7.  Phenotypic and genotypic methods for identification of slime layer production, efflux pump activity, and antimicrobial resistance genes as potential causes of the antimicrobial resistance of some mastitis pathogens from farms in Menoufia, Egypt.

Authors:  Mohamed Sabry Abd Elraheam Elsayed; Tamer Roshdey; Ahmed Salah; Reda Tarabees; Gamal Younis; Doaa Eldeep
Journal:  Mol Biol Rep       Date:  2019-10-03       Impact factor: 2.316

8.  Effect of Carvacrol and Thymol on NorA efflux pump inhibition in multidrug-resistant (MDR) Staphylococcus aureus strains.

Authors:  Cristina Rodrigues Dos Santos Barbosa; Jackelyne Roberta Scherf; Thiago Sampaio de Freitas; Irwin Rose Alencar de Menezes; Raimundo Luiz Silva Pereira; Joycy Francely Sampaio Dos Santos; Sarah Silva Patrício de Jesus; Thais Pereira Lopes; Zildene de Sousa Silveira; Cícera Datiane de Morais Oliveira-Tintino; José Pinto Siqueira Júnior; Henrique Douglas Melo Coutinho; Saulo Relison Tintino; Francisco Assis Bezerra da Cunha
Journal:  J Bioenerg Biomembr       Date:  2021-06-22       Impact factor: 2.945

9.  Cystic Fibrosis Sputum Impairs the Ability of Neutrophils to Kill Staphylococcus aureus.

Authors:  Kayla Fantone; Samantha L Tucker; Arthur Miller; Ruchi Yadav; Eryn E Bernardy; Rachel Fricker; Arlene A Stecenko; Joanna B Goldberg; Balázs Rada
Journal:  Pathogens       Date:  2021-06-04

Review 10.  Emerging Nanomedicine Therapies to Counter the Rise of Methicillin-Resistant Staphylococcus aureus.

Authors:  Alan Hibbitts; Cian O'Leary
Journal:  Materials (Basel)       Date:  2018-02-23       Impact factor: 3.623
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