Literature DB >> 9527807

Effects of probenecid and cimetidine on renal disposition of ofloxacin in rats.

E F Foote1, C E Halstenson.   

Abstract

The renal handling of ofloxacin in rats which were given ofloxacin either alone or in combination with probenecid or cimetidine was studied. In the presence of cimetidine or probenecid, ofloxacin's total and renal clearances were reduced and its half-life was prolonged. This suggests that ofloxacin is secreted by both the anionic and cationic transport systems.

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Year:  1998        PMID： 9527807      PMCID： PMC105435          DOI： 10.1128/AAC.42.2.456

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

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8.  Cinoxacin: competitive inhibitory effect on p-aminohippurate transport and its uptake in renal cortical slices.

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9.  Effect of cimetidine on the pharmacokinetics of temafloxacin.

Authors:  F Sörgel; G R Granneman; U Stephan; C Locke
Journal:  Clin Pharmacokinet       Date:  1992       Impact factor: 6.447

10.  Renal excretion of cimetidine.

Authors:  I M Weiner; L Roth
Journal:  J Pharmacol Exp Ther       Date:  1981-03       Impact factor: 4.030
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  9 in total

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5.  Interactions of ofloxacin and erythromycin with the multidrug resistance protein (MRP) in MRP-overexpressing human leukemia cells.

Authors:  K Terashi; M Oka; H Soda; M Fukuda; S Kawabata; K Nakatomi; K Shiozawa; T Nakamura; K Tsukamoto; Y Noguchi; M Suenaga; C Tei; S Kohno
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Review 6.  Ofloxacin. A reappraisal of its use in the management of genitourinary tract infections.

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7.  Organic anion transporter 3 (oat3/slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin.

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8.  Potential pharmacokinetic role of organic cation transporters in modulating the transcorneal penetration of its substrates administered topically.

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9.  Effects of membrane transport activity and cell metabolism on the unbound drug concentrations in the skeletal muscle and liver of drugs: A microdialysis study in rats.

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Journal:  Pharmacol Res Perspect       Date:  2021-10
  9 in total

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