Literature DB >> 16377715

Norfloxacin blood-brain barrier transport in rats is not affected by probenecid coadministration.

Sandrine Marchand1, Anna Forsell, Marylore Chenel, Emmanuelle Comets, Isabelle Lamarche, William Couet.   

Abstract

The effect of probenecid (PRO) on norfloxacin (NOR) blood-brain barrier transport was investigated with rats by microdialysis. Maximum brain drug concentrations were rapidly attained, and the brain penetration factor was close to 5% in the absence and presence of PRO. In conclusion, PRO has no effect on NOR blood-brain barrier transport.

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Year:  2006        PMID： 16377715      PMCID： PMC1346768          DOI： 10.1128/AAC.50.1.371-373.2006

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

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2.  Dose ranging pharmacokinetics and brain distribution of norfloxacin using microdialysis in rats.

Authors:  Sandrine Marchand; Marylore Chenel; Isabelle Lamarche; Claudine Pariat; William Couet
Journal:  J Pharm Sci       Date:  2003-12       Impact factor: 3.534

3.  Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier.

Authors:  D Sugiyama; H Kusuhara; Y Shitara; T Abe; P J Meier; T Sekine; H Endou; H Suzuki; Y Sugiyama
Journal:  J Pharmacol Exp Ther       Date:  2001-07       Impact factor: 4.030

4.  Mechanism of renal excretion of AM-715, a new quinolonecarboxylic acid derivative, in rabbits, dogs, and humans.

Authors:  J Shimada; T Yamaji; Y Ueda; H Uchida; H Kusajima; T Irikura
Journal:  Antimicrob Agents Chemother       Date:  1983-01       Impact factor: 5.191

5.  Modelling of the blood-brain barrier transport of morphine-3-glucuronide studied using microdialysis in the rat: involvement of probenecid-sensitive transport.

Authors:  R Xie; M R Bouw; M Hammarlund-Udenaes
Journal:  Br J Pharmacol       Date:  2000-12       Impact factor: 8.739

6.  Central nervous system toxicity of quinolones: human and animal findings.

Authors:  W Christ
Journal:  J Antimicrob Chemother       Date:  1990-10       Impact factor: 5.790

7.  Microdialysis study of imipenem distribution in skeletal muscle and lung extracellular fluids of noninfected rats.

Authors:  Sandrine Marchand; Claire Dahyot; Isabelle Lamarche; Olivier Mimoz; William Couet
Journal:  Antimicrob Agents Chemother       Date:  2005-06       Impact factor: 5.191

8.  Morphine blood-brain barrier transport is influenced by probenecid co-administration.

Authors:  Karin Tunblad; E Niclas Jonsson; Margareta Hammarlund-Udenaes
Journal:  Pharm Res       Date:  2003-04       Impact factor: 4.200

9.  Distributional transport kinetics of zidovudine between plasma and brain extracellular fluid/cerebrospinal fluid in the rabbit: investigation of the inhibitory effect of probenecid utilizing microdialysis.

Authors:  S L Wong; K Van Belle; R J Sawchuk
Journal:  J Pharmacol Exp Ther       Date:  1993-02       Impact factor: 4.030

10.  Simultaneous central nervous system distribution and pharmacokinetic-pharmacodynamic modelling of the electroencephalogram effect of norfloxacin administered at a convulsant dose in rats.

Authors:  Marylore Chenel; Sandrine Marchand; Antoine Dupuis; Isabelle Lamarche; Joël Paquereau; Claudine Pariat; William Couet
Journal:  Br J Pharmacol       Date:  2004-05       Impact factor: 8.739
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  2 in total

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Journal:  Pharm Res       Date:  2015-06-04       Impact factor: 4.200

Review 2.  On the rate and extent of drug delivery to the brain.

Authors:  Margareta Hammarlund-Udenaes; Markus Fridén; Stina Syvänen; Anubha Gupta
Journal:  Pharm Res       Date:  2007-12-05       Impact factor: 4.200
  2 in total

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