Literature DB >> 10817732

Interactions of ofloxacin and erythromycin with the multidrug resistance protein (MRP) in MRP-overexpressing human leukemia cells.

K Terashi1, M Oka, H Soda, M Fukuda, S Kawabata, K Nakatomi, K Shiozawa, T Nakamura, K Tsukamoto, Y Noguchi, M Suenaga, C Tei, S Kohno.   

Abstract

To investigate interactions between the multidrug resistance protein (MRP) and antimicrobial agents, we examined the effects of 12 agents on vincristine sensitivity and efflux of the calcein acetoxy-methyl ester (calcein-AM) of a MRP substrate in MRP-overexpressing cells. Only ofloxacin and erythromycin enhanced sensitivity with increased intracellular vincristine accumulation and inhibited the calcein-AM efflux. Our findings suggest that the two agents are possible MRP substrates and may competitively inhibit MRP function as a drug efflux pump.

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Year:  2000        PMID： 10817732      PMCID： PMC89936          DOI： 10.1128/AAC.44.6.1697-1700.2000

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

1.  Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells.

Authors:  M Kool; M van der Linden; M de Haas; F Baas; P Borst
Journal:  Cancer Res       Date:  1999-01-01       Impact factor: 12.701

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Journal:  J Immunol Methods       Date:  1983-12-16       Impact factor: 2.303

5.  Interaction of ofloxacin with organic cation transport system in rat renal brush-border membranes.

Authors:  T Okano; H Maegawa; K Inui; R Hori
Journal:  J Pharmacol Exp Ther       Date:  1990-12       Impact factor: 4.030

6.  Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells.

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Journal:  Eur J Pharmacol       Date:  1998-10-09       Impact factor: 4.432

7.  Tissue distribution of the multidrug resistance protein.

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Journal:  Am J Pathol       Date:  1996-04       Impact factor: 4.307

8.  Difloxacin reverses multidrug resistance in HL-60/AR cells that overexpress the multidrug resistance-related protein (MRP) gene.

Authors:  S Gollapudi; F Thadepalli; C H Kim; S Gupta
Journal:  Oncol Res       Date:  1995       Impact factor: 5.574

9.  Calcein accumulation as a fluorometric functional assay of the multidrug transporter.

Authors:  Z Holló; L Homolya; C W Davis; B Sarkadi
Journal:  Biochim Biophys Acta       Date:  1994-05-11

10.  Functional detection of MDR1/P170 and MRP/P190-mediated multidrug resistance in tumour cells by flow cytometry.

Authors:  N Feller; C M Kuiper; J Lankelma; J K Ruhdal; R J Scheper; H M Pinedo; H J Broxterman
Journal:  Br J Cancer       Date:  1995-09       Impact factor: 7.640
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  8 in total

1.  Hepatic disposition of ximelagatran and its metabolites in pig; prediction of the impact of membrane transporters through a simple disposition model.

Authors:  Erik Sjögren; Ulf Bredberg; Erik Allard; Björn Arvidsson; Jonas Bergquist; Tommy B Andersson; Hans Lennernäs
Journal:  Pharm Res       Date:  2010-02-06       Impact factor: 4.200

2.  Cellular accumulation and activity of quinolones in ciprofloxacin-resistant J774 macrophages.

Authors:  Jean-Michel Michot; Marie F Heremans; Nancy E Caceres; Marie-Paule Mingeot-Leclercq; Paul M Tulkens; Françoise Van Bambeke
Journal:  Antimicrob Agents Chemother       Date:  2006-05       Impact factor: 5.191

3.  Multidrug resistance protein 1 (MRP1) in rabbit conjunctival epithelial cells: its effect on drug efflux and its regulation by adenoviral infection.

Authors:  Johnny J Yang; David K Ann; Ram Kannan; Vincent H L Lee
Journal:  Pharm Res       Date:  2007-04-03       Impact factor: 4.200

4.  Molecular evidence and functional expression of a novel drug efflux pump (ABCC2) in human corneal epithelium and rabbit cornea and its role in ocular drug efflux.

Authors:  Pradeep K Karla; Dhananjay Pal; Tim Quinn; Ashim K Mitra
Journal:  Int J Pharm       Date:  2006-11-15       Impact factor: 5.875

5.  Effluxing ABC transporters in human corneal epithelium.

Authors:  Kati-Sisko Vellonen; Eliisa Mannermaa; Helen Turner; Marika Häkli; J Mario Wolosin; Timo Tervo; Paavo Honkakoski; Arto Urtti
Journal:  J Pharm Sci       Date:  2010-02       Impact factor: 3.534

6.  ABC transporters and isothiocyanates: potential for pharmacokinetic diet-drug interactions.

Authors:  Urvi Telang; Yan Ji; Marilyn E Morris
Journal:  Biopharm Drug Dispos       Date:  2009-10       Impact factor: 1.627

7.  ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal.

Authors:  Cheol-Hee Choi
Journal:  Cancer Cell Int       Date:  2005-10-04       Impact factor: 5.722

8.  Cytotoxic drug sensitivity of Epstein-Barr virus transformed lymphoblastoid B-cells.

Authors:  Laszlo Markasz; György Stuber; Emilie Flaberg; Asa Gustafsson Jernberg; Staffan Eksborg; Eva Olah; Henriette Skribek; Laszlo Szekely
Journal:  BMC Cancer       Date:  2006-11-13       Impact factor: 4.430
  8 in total

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