Literature DB >> 9521156

A simple whole-blood test for detecting antibodies to human immunodeficiency virus.

W Schramm1, S E Wade, G Barriga Angulo, P Castillo Torres, A Burgess-Cassler.   

Abstract

We developed an immunochromatographic whole-blood test (WBT) which detects antibodies to human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) from fingerstick blood. The sensitivity and specificity of the WBT were 99.41% (1,018 confirmed positive patients) and 99.89% (941 uninfected patients), respectively (enzyme immunoassay [EIA] on serum or plasma as a reference). WBT performance was comparable to those of licensed EIAs and Western blotting, using 18 HIV-2 sera, 23 HIV-1 seroconversion panels, and a low-titer performance panel (in lieu of whole blood).

Entities:  

Mesh：

Year:  1998        PMID： 9521156      PMCID： PMC121371          DOI： 10.1128/CDLI.5.2.263-265.1998

Source DB:  PubMed          Journal:  Clin Diagn Lab Immunol        ISSN： 1071-412X


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Authors:  A Burgess-Cassler; G Barriga Angulo; S E Wade; P Castillo Torres; W Schramm
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10.  Multisite evaluation of four anti-HIV-1/HIV-2 enzyme immunoassays. Australian HIV Test Evaluation Group.

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  10 in total
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Authors:  Anne Harwood Peruski; Leonard F Peruski
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