Literature DB >> 9515582

Effects of camptothecin, a topoisomerase I inhibitor, on Plasmodium falciparum.

A L Bodley1, J N Cumming, T A Shapiro.   

Abstract

Currently, the treatment of falciparum malaria is seriously compromised by spreading drug resistance. We studied the effects of camptothecin, a potent and specific topoisomerase I inhibitor, on erythrocytic malaria parasites in vitro. In Plasmodium falciparum, camptothecin trapped protein-DNA complexes, inhibited nucleic acid biosynthesis, and was cytotoxic. These results provide proof for the concept that topoisomerase I is a vulnerable target for new antimalarial drug development.

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Year:  1998        PMID： 9515582     DOI： 10.1016/s0006-2952(97)00556-x

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  12 in total

1.  Theileria apicoplast as a target for chemotherapy.

Authors:  Regina Lizundia; Dirk Werling; Gordon Langsley; Stuart A Ralph
Journal:  Antimicrob Agents Chemother       Date:  2008-12-15       Impact factor: 5.191

Review 2.  DNA topoisomerases in apicomplexan parasites: promising targets for drug discovery.

Authors:  Carlos García-Estrada; Christopher Fernández Prada; Celia Fernández-Rubio; Francisco Rojo-Vázquez; Rafael Balaña-Fouce
Journal:  Proc Biol Sci       Date:  2010-03-03       Impact factor: 5.349

Review 3.  Perspectives on biologically active camptothecin derivatives.

Authors:  Ying-Qian Liu; Wen-Qun Li; Susan L Morris-Natschke; Keduo Qian; Liu Yang; Gao-Xiang Zhu; Xiao-Bing Wu; An-Liang Chen; Shao-Yong Zhang; Xiang Nan; Kuo-Hsiung Lee
Journal:  Med Res Rev       Date:  2015-03-21       Impact factor: 12.944

Review 4.  A tale of topoisomerases and the knotty genetic material in the backdrop of Plasmodium biology.

Authors:  Priyanka Singh; Khushboo Rani; Akanksha Gotmare; Sunanda Bhattacharyya
Journal:  Biosci Rep       Date:  2022-06-30       Impact factor: 3.976

5.  Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis.

Authors:  Carola Huthmacher; Andreas Hoppe; Sascha Bulik; Hermann-Georg Holzhütter
Journal:  BMC Syst Biol       Date:  2010-08-31

6.  The Plant Alkaloid Camptothecin as a Novel Antifouling Compound for Marine Paints: Laboratory Bioassays and Field Trials.

Authors:  Dan Qing Feng; Jian He; Si Yu Chen; Pei Su; Cai Huan Ke; Wei Wang
Journal:  Mar Biotechnol (NY)       Date:  2018-06-02       Impact factor: 3.619

7.  Production of camptothecin in cultures of Chonemorpha grandiflora.

Authors:  A V Kulkarni; A A Patwardhan; U Lele; N P Malpathak
Journal:  Pharmacognosy Res       Date:  2010-09

8.  Deletion study of DNA topoisomerase IB from Leishmania donovani: searching for a minimal functional heterodimer.

Authors:  Rosario Díaz González; Yolanda Pérez Pertejo; David Ordóñez; Rafael Balaña-Fouce; Rosa M Reguera
Journal:  PLoS One       Date:  2007-11-14       Impact factor: 3.240

9.  Effect of precursors feeding and media manipulation on production of novel anticancer pro-drug camptothecin from endophytic fungus.

Authors:  Touseef Amna; Musarat Amina; P R Sharma; S C Puri; Hanan M Al-Youssef; Areej M Al-Taweel; G N Qazi
Journal:  Braz J Microbiol       Date:  2012-06-01       Impact factor: 2.476

10.  Theoretical and experimental studies of new modified isoflavonoids as potential inhibitors of topoisomerase I from Plasmodium falciparum.

Authors:  Wilian A Cortopassi; Julia Penna-Coutinho; Anna C C Aguiar; André S Pimentel; Camilla D Buarque; Paulo R R Costa; Bruna R M Alves; Tanos C C França; Antoniana U Krettli
Journal:  PLoS One       Date:  2014-03-20       Impact factor: 3.240
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