Literature DB >> 9502313

The construction of metal centers in proteins by rational design.

H W Hellinga1.   

Abstract

Metalloprotein properties result from the interplay between coordination requirements of the metal center, protein stability, and modulation of the metal center by the surrounding protein matrix. Simple metal centers, which exercise control over the protein by affecting stability or enzyme activity, have been created by rational design. Complex centers, which require control by the protein matrix, have also been constructed.

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Year:  1998        PMID: 9502313     DOI: 10.1016/S1359-0278(98)00001-7

Source DB:  PubMed          Journal:  Fold Des        ISSN: 1359-0278


  19 in total

Review 1.  De novo design of helical bundles as models for understanding protein folding and function.

Authors:  R B Hill; D P Raleigh; A Lombardi; W F DeGrado
Journal:  Acc Chem Res       Date:  2000-11       Impact factor: 22.384

2.  Computational design of a Zn2+ receptor that controls bacterial gene expression.

Authors:  M A Dwyer; L L Looger; H W Hellinga
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-19       Impact factor: 11.205

3.  Solution structure and dynamics of a de novo designed three-helix bundle protein.

Authors:  S T Walsh; H Cheng; J W Bryson; H Roder; W F DeGrado
Journal:  Proc Natl Acad Sci U S A       Date:  1999-05-11       Impact factor: 11.205

4.  Designing functional metalloproteins: from structural to catalytic metal sites.

Authors:  Melissa L Zastrow; Vincent L Pecoraro
Journal:  Coord Chem Rev       Date:  2013-09       Impact factor: 22.315

5.  Metalloprotein and metallo-DNA/RNAzyme design: current approaches, success measures, and future challenges.

Authors:  Yi Lu
Journal:  Inorg Chem       Date:  2006-12-11       Impact factor: 5.165

Review 6.  Protein design: toward functional metalloenzymes.

Authors:  Fangting Yu; Virginia M Cangelosi; Melissa L Zastrow; Matteo Tegoni; Jefferson S Plegaria; Alison G Tebo; Catherine S Mocny; Leela Ruckthong; Hira Qayyum; Vincent L Pecoraro
Journal:  Chem Rev       Date:  2014-03-24       Impact factor: 60.622

7.  Design of a three-helix bundle capable of binding heavy metals in a triscysteine environment.

Authors:  Saumen Chakraborty; Joslyn Yudenfreund Kravitz; Peter W Thulstrup; Lars Hemmingsen; William F DeGrado; Vincent L Pecoraro
Journal:  Angew Chem Int Ed Engl       Date:  2011-02-15       Impact factor: 15.336

8.  Introduction and characterization of a functionally linked metal ion binding site at the exposed heme edge of myoglobin.

Authors:  Christie L Hunter; Robert Maurus; Marcia R Mauk; Hung Lee; Emma L Raven; Harry Tong; Nham Nguyen; Michael Smith; Gary D Brayer; A Grant Mauk
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-18       Impact factor: 11.205

9.  Orthogonal site-specific protein modification by engineering reversible thiol protection mechanisms.

Authors:  J Jefferson Smith; David W Conrad; Matthew J Cuneo; Homme W Hellinga
Journal:  Protein Sci       Date:  2004-12-02       Impact factor: 6.725

10.  De novo designed cyclic-peptide heme complexes.

Authors:  Michael M Rosenblatt; Jiangyun Wang; Kenneth S Suslick
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-31       Impact factor: 11.205

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