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Literature DB >> 9500546

Distribution of olfactory receptor genes in the human genome.

S Rouquier¹, S Taviaux, B J Trask, V Brand-Arpon, G van den Engh, J Demaille, D Giorgi.

Abstract

We demonstrate that members of the olfactory receptor (OR) gene family are distributed on all but a few human chromosomes. Through FISH analysis, we show that OR sequences reside at more than 25 locations in the human genome. Their distribution is biased for terminal bands. Flow-sorted chromosomes were used to isolate 87 OR sequences derived from 16 chromosomes. Their sequence-relationships are indicative of the inter- and intrachromosomal duplications responsible for OR family expansion. The human genome has accumulated a striking number of dysfunctional copies: 72% of the sequences are pseudogenes. ORF-containing sequences predominate on chromosomes 7, 16 and 17.

Entities: Gene Species

Mesh：

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Year: 1998 PMID： 9500546 DOI： 10.1038/ng0398-243

Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330

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Cited

47 in total

1. The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates.

Authors: S Rouquier; A Blancher; D Giorgi
Journal: Proc Natl Acad Sci U S A Date: 2000-03-14 Impact factor: 11.205

2. Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes.

Authors: M Bulger; J H van Doorninck; N Saitoh; A Telling; C Farrell; M A Bender; G Felsenfeld; R Axel; M Groudine; J H von Doorninck
Journal: Proc Natl Acad Sci U S A Date: 1999-04-27 Impact factor: 11.205

3. A cascade of complex subtelomeric duplications during the evolution of the hominoid and Old World monkey genomes.

Authors: Michel van Geel; Evan E Eichler; Amy F Beck; Zhihong Shan; Thomas Haaf; Silvère M van der Maarel; Rune R Frants; Pieter J de Jong
Journal: Am J Hum Genet Date: 2001-11-30 Impact factor: 11.025

4. Genomic anatomy of a premier major histocompatibility complex paralogous region on chromosome 1q21-q22.

Authors: T Shiina; A Ando; Y Suto; F Kasai; A Shigenari; N Takishima; E Kikkawa; K Iwata; Y Kuwano; Y Kitamura; Y Matsuzawa; K Sano; M Nogami; H Kawata; S Li; Y Fukuzumi; M Yamazaki; H Tashiro; G Tamiya; A Kohda; K Okumura; T Ikemura; E Soeda; N Mizuki; M Kimura; S Bahram; H Inoko
Journal: Genome Res Date: 2001-05 Impact factor: 9.043

5. The variable and conserved interfaces of modeled olfactory receptor proteins.

Authors: Y Pilpel; D Lancet
Journal: Protein Sci Date: 1999-05 Impact factor: 6.725

6. The clustered olfactory receptor gene family 262: genomic organization, promotor elements, and interacting transcription factors.

Authors: Reiner Hoppe; Henning Frank; Heinz Breer; Jörg Strotmann
Journal: Genome Res Date: 2003-12 Impact factor: 9.043

Distribution of olfactory receptor genes in the human genome.

1. The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates.

2. Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes.

3. A cascade of complex subtelomeric duplications during the evolution of the hominoid and Old World monkey genomes.

4. Genomic anatomy of a premier major histocompatibility complex paralogous region on chromosome 1q21-q22.

5. The variable and conserved interfaces of modeled olfactory receptor proteins.

6. The clustered olfactory receptor gene family 262: genomic organization, promotor elements, and interacting transcription factors.

7. Evolution of olfactory receptor genes in the human genome.

8. Evolution and comparative genomics of odorant- and pheromone-associated genes in rodents.

9. The olfactory capability of dogs to discriminate between different quantities of food.

10. The fluid dynamics of canine olfaction: unique nasal airflow patterns as an explanation of macrosmia.