Literature DB >> 9479474

Structural insights into DNA polymerase beta fidelity: hold tight if you want it right.

W A Beard1, S H Wilson.   

Abstract

DNA polymerases must select and incorporate the correct deoxynucleoside 5'-triphosphate from a pool of structurally similar molecules. The structural and kinetic characterization of DNA polymerase beta indicates that this polymerase must stabilize the templating base to achieve efficient polymerization with high fidelity.

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Year:  1998        PMID： 9479474     DOI： 10.1016/s1074-5521(98)90081-3

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  29 in total

1.  Orchestration of cooperative events in DNA synthesis and repair mechanism unraveled by transition path sampling of DNA polymerase beta's closing.

Authors:  Ravi Radhakrishnan; Tamar Schlick
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-06       Impact factor: 11.205

2.  Kinetic analysis of 3'-5' nucleotide addition catalyzed by eukaryotic tRNA(His) guanylyltransferase.

Authors:  Brian A Smith; Jane E Jackman
Journal:  Biochemistry       Date:  2011-12-14       Impact factor: 3.162

3.  In silico studies of the African swine fever virus DNA polymerase X support an induced-fit mechanism.

Authors:  Benedetta A Sampoli Benítez; Karunesh Arora; Tamar Schlick
Journal:  Biophys J       Date:  2005-10-07       Impact factor: 4.033

4.  Exploring the role of large conformational changes in the fidelity of DNA polymerase beta.

Authors:  Yun Xiang; Myron F Goodman; William A Beard; Samuel H Wilson; Arieh Warshel
Journal:  Proteins       Date:  2008-01-01

Review 5.  DNA adduct structure-function relationships: comparing solution with polymerase structures.

Authors:  Suse Broyde; Lihua Wang; Ling Zhang; Olga Rechkoblit; Nicholas E Geacintov; Dinshaw J Patel
Journal:  Chem Res Toxicol       Date:  2007-12-04       Impact factor: 3.739

Review 6.  The X family portrait: structural insights into biological functions of X family polymerases.

Authors:  Andrea F Moon; Miguel Garcia-Diaz; Vinod K Batra; William A Beard; Katarzyna Bebenek; Thomas A Kunkel; Samuel H Wilson; Lars C Pedersen
Journal:  DNA Repair (Amst)       Date:  2007-07-12

Review 7.  Regulation of DNA repair fidelity by molecular checkpoints: "gates" in DNA polymerase beta's substrate selection.

Authors:  Ravi Radhakrishnan; Karunesh Arora; Yanli Wang; William A Beard; Samuel H Wilson; Tamar Schlick
Journal:  Biochemistry       Date:  2006-12-01       Impact factor: 3.162

Review 8.  DNA polymerase family X: function, structure, and cellular roles.

Authors:  Jennifer Yamtich; Joann B Sweasy
Journal:  Biochim Biophys Acta       Date:  2009-07-23

9.  I260Q DNA polymerase β highlights precatalytic conformational rearrangements critical for fidelity.

Authors:  Cary Liptak; Mariam M Mahmoud; Brian E Eckenroth; Marcus V Moreno; Kyle East; Khadijeh S Alnajjar; Ji Huang; Jamie B Towle-Weicksel; Sylvie Doublié; J Patrick Loria; Joann B Sweasy
Journal:  Nucleic Acids Res       Date:  2018-11-16       Impact factor: 16.971

10.  Crystal structures of a template-independent DNA polymerase: murine terminal deoxynucleotidyltransferase.

Authors:  M Delarue; J B Boulé; J Lescar; N Expert-Bezançon; N Jourdan; N Sukumar; F Rougeon; C Papanicolaou
Journal:  EMBO J       Date:  2002-02-01       Impact factor: 11.598
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