Literature DB >> 9476963

Suppression of growth and transformation and induction of apoptosis by EGR-1.

C Liu1, V M Rangnekar, E Adamson, D Mercola.   

Abstract

Although cloned as an "immediate-early gene," recent studies show that EGR-1 functions in growth regulation and suppression of transformation by transactivation of the transforming growth factor beta-1 (TGF-beta1) gene and cooperation with Sp1, Jun-B, p21WAF1/Cip1, and stimulates apoptosis by transactivation of the p53 gene.

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Year:  1998        PMID： 9476963

Source DB:  PubMed          Journal:  Cancer Gene Ther        ISSN： 0929-1903            Impact factor:   5.987


  72 in total

Review 1.  Pathways of Egr-1-mediated gene transcription in vascular biology.

Authors:  E S Silverman; T Collins
Journal:  Am J Pathol       Date:  1999-03       Impact factor: 4.307

2.  COUP-TF upregulates NGFI-A gene expression through an Sp1 binding site.

Authors:  C Pipaón; S Y Tsai; M J Tsai
Journal:  Mol Cell Biol       Date:  1999-04       Impact factor: 4.272

Review 3.  Egr-1 is a major vascular pathogenic transcription factor in atherosclerosis and restenosis.

Authors:  Florian Blaschke; Dennis Bruemmer; Ronald E Law
Journal:  Rev Endocr Metab Disord       Date:  2004-08       Impact factor: 6.514

4.  GGPPS, a new EGR-1 target gene, reactivates ERK 1/2 signaling through increasing Ras prenylation.

Authors:  Ning Shen; Yue Shao; Shan-Shan Lai; Long Qiao; Run-Lin Yang; Bin Xue; Fei-Yan Pan; Hua-Qun Chen; Chao-Jun Li
Journal:  Am J Pathol       Date:  2011-10-06       Impact factor: 4.307

5.  High salt culture conditions suppress proliferation of rat C6 glioma cell by arresting cell-cycle progression at S-phase.

Authors:  Hideki Arimochi; Kyoji Morita
Journal:  J Mol Neurosci       Date:  2005       Impact factor: 3.444

Review 6.  Towards a molecular understanding of the differential signals regulating alphabeta/gammadelta T lineage choice.

Authors:  Sang-Yun Lee; Jason Stadanlick; Dietmar J Kappes; David L Wiest
Journal:  Semin Immunol       Date:  2010-05-14       Impact factor: 11.130

7.  Expression of immediate early genes, GATA-4, and Nkx-2.5 in adrenergic-induced cardiac hypertrophy and during regression in adult mice.

Authors:  N Saadane; L Alpert; L E Chalifour
Journal:  Br J Pharmacol       Date:  1999-07       Impact factor: 8.739

8.  Green tea catechin (-)-epicatechin gallate induces tumour suppressor protein ATF3 via EGR-1 activation.

Authors:  Kyou-Nam Cho; Mugdha Sukhthankar; Seong-Ho Lee; Joo-Heon Yoon; Seung Joon Baek
Journal:  Eur J Cancer       Date:  2007-08-30       Impact factor: 9.162

9.  Targeted knockdown of EGR-1 inhibits IL-8 production and IL-8-mediated invasion of prostate cancer cells through suppressing EGR-1/NF-kappaB synergy.

Authors:  Jiajia Ma; Zijia Ren; Yang Ma; Lu Xu; Ying Zhao; Chaogu Zheng; Yinghui Fang; Ting Xue; Baolin Sun; Weihua Xiao
Journal:  J Biol Chem       Date:  2009-10-16       Impact factor: 5.157

10.  Identification of early growth response protein 1 (EGR-1) as a novel target for JUN-induced apoptosis in multiple myeloma.

Authors:  Lijuan Chen; Siqing Wang; Yiming Zhou; Xiaosong Wu; Igor Entin; Joshua Epstein; Shmuel Yaccoby; Wei Xiong; Bart Barlogie; John D Shaughnessy; Fenghuang Zhan
Journal:  Blood       Date:  2009-10-16       Impact factor: 22.113
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