| Literature DB >> 9473697 |
S Rasmuson1, T Olsson, B G Henriksson, P A Kelly, M C Holmes, J R Seckl, A H Mohammed.
Abstract
Environmental enrichment augments neuronal plasticity and cognitive function and possible mediators of these changes are of considerable interest. In this study, male rats were exposed to environmental enrichment or single housing for 30 days. Rats from the enriched group had significantly higher 5-HT1A receptor mRNA expression in the dorsal hippocampus (62%, 59% and 44% increase in the CA1, CA2 and CA3 subfields, respectively). This was associated with significantly higher [3H]8-OH-DPAT binding in the inferior part of CA1. No changes were seen for 5-HT2A or 5-HT2C receptor mRNAs. The neuronal plasticity detected after environmental change may be mediated, in part, through 5-HT1A receptors.Entities:
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Year: 1998 PMID： 9473697 DOI： 10.1016/s0169-328x(97)00317-3
Source DB: PubMed Journal: Brain Res Mol Brain Res ISSN： 0169-328X