Literature DB >> 26851834

The 5-HT1A receptor in Major Depressive Disorder.

Joshua Kaufman1, Christine DeLorenzo2, Sunia Choudhury2, Ramin V Parsey2.   

Abstract

Major Depressive Disorder (MDD) is a highly prevalent psychiatric diagnosis that is associated with a high degree of morbidity and mortality. This debilitating disorder is currently one of the leading causes of disability nationwide and is predicted to be the leading cause of disease burden by the year 2030. A large body of previous research has theorized that serotonergic dysfunction, specifically of the serotonin (5-HT) 1A receptor, plays a key role in the development of MDD. The purpose of this review is to describe the evolution of our current understanding of the serotonin 1A (5-HT1A) receptor and its role in the pathophysiology MDD through the discussion of animal, post-mortem, positron emission tomography (PET), pharmacologic and genetic studies.
Copyright © 2016 Elsevier B.V. and ECNP. All rights reserved.

Entities:  

Keywords:  5-HT1A; Depression; Review

Mesh：

Substances：

Year:  2016        PMID： 26851834      PMCID： PMC5192019          DOI： 10.1016/j.euroneuro.2015.12.039

Source DB:  PubMed          Journal:  Eur Neuropsychopharmacol        ISSN： 0924-977X            Impact factor:   4.600


  109 in total

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