Literature DB >> 12223535

Environmental enrichment reverses the effects of maternal separation on stress reactivity.

Darlene D Francis1, Josie Diorio, Paul M Plotsky, Michael J Meaney.   

Abstract

Postnatal maternal separation increases hypothalamic corticotropin-releasing factor (CRF) gene expression and hypothalamic-pituitary-adrenal (HPA) and behavioral responses to stress. We report here that environmental enrichment during the peripubertal period completely reverses the effects of maternal separation on both HPA and behavioral responses to stress, with no effect on CRF mRNA expression. We conclude that environmental enrichment leads to a functional reversal of the effects of maternal separation through compensation for, rather than reversal of, the neural effects of early life adversity.

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Year:  2002        PMID： 12223535      PMCID： PMC6758090     

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.167


  34 in total

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2.  Rearing environmental enrichment in two inbred strains of mice: 1. Effects on emotional reactivity.

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Review 3.  Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations.

Authors:  M J Meaney
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Journal:  Mol Endocrinol       Date:  2000-04

Review 6.  Neonatal handling and environmental enrichment effects on emotionality, novelty/reward seeking, and age-related cognitive and hippocampal impairments: focus on the Roman rat lines.

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Review 10.  Brain corticosteroid receptor balance in health and disease.

Authors:  E R De Kloet; E Vreugdenhil; M S Oitzl; M Joëls
Journal:  Endocr Rev       Date:  1998-06       Impact factor: 19.871
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  159 in total

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Review 9.  [Current aspects of attachment theory and development psychology as well as neurobiological aspects in psychiatric and psychosomatic disorders].

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Review 10.  Neurodevelopmental Optimization after Early-Life Adversity: Cross-Species Studies to Elucidate Sensitive Periods and Brain Mechanisms to Inform Early Intervention.

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