Literature DB >> 9459296

Thermodynamic and spectral properties of DNA miniduplexes with the terminal G x A mispairs and 3' or 5' dangling bases.

S G Lokhov1, D V Pyshnyi.   

Abstract

The tetradeoxyribonucleotide pAGCG in 1 M NaCl forms duplexes with terminal non-canonical pA x G pairs with stability significantly exceeding that for the duplex (pAGCT)2 and lower than that for the duplex (pCGCG)2. The deoxyriboduplex (pAGCG)2 is considerably stabilized by 3'-Y and slightly by 5'-X dangling bases. Therefore, the stability of duplexes with 3' dangling bases decreases in the order (pAGCGY)2 > (pCGCGA)2 > (pAGCTA)2. The sum of the independent stabilizing effect of the of 5'-pG and 3'-A dangling bases on the (pAGCG)2 core duplex is higher than that of the additional terminal pG x A pair in pG-A-/-G-A tandem of the duplex (pGAGCGA)2.

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Year:  1997        PMID： 9459296     DOI： 10.1016/s0014-5793(97)01502-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

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Journal:  Nucleic Acids Res       Date:  2000-01-15       Impact factor: 16.971

2.  Thermodynamic parameters for calculating the stability of complexes of bridged oligonucleotides.

Authors:  A A Lomzov; I A Pyshnaya; E M Ivanova; D V Pyshnyi
Journal:  Dokl Biochem Biophys       Date:  2006 Jul-Aug       Impact factor: 0.788

3.  Reduced aggregation and improved specificity of G-rich oligodeoxyribonucleotides containing pyrazolo[3,4-d]pyrimidine guanine bases.

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Journal:  Nucleic Acids Res       Date:  2002-11-15       Impact factor: 16.971

4.  A mutation-resistant deoxyribozyme OR gate for highly selective detection of viral nucleic acids.

Authors:  Ola Kamar; Sin-Cih Sun; Chieh-Hua Lin; Wan-Yu Chung; Min-Shi Lee; Yu-Chieh Liao; Dmitry M Kolpashchikov; Min-Chieh Chuang
Journal:  Chem Commun (Camb)       Date:  2017-09-21       Impact factor: 6.222

5.  Oxidative damage to epigenetically methylated sites affects DNA stability, dynamics and enzymatic demethylation.

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7.  Nucleotide Modifications Decrease Innate Immune Response Induced by Synthetic Analogs of snRNAs and snoRNAs.

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8.  Melting temperature measurement and mesoscopic evaluation of single, double and triple DNA mismatches.

Authors:  Luciana M Oliveira; Adam S Long; Tom Brown; Keith R Fox; Gerald Weber
Journal:  Chem Sci       Date:  2020-07-23       Impact factor: 9.825
  8 in total

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