| Literature DB >> 9452136 |
Abstract
Steroidogenesis depends on the rate of cholesterol transport from intracellular stores to the inner mitochondrial membrane cytochrome P-450 side-chain cleavage enzyme. Using steroidogenic cell submitochondrial fractions, mitochondrial preparations, various cell models, and animal models and with the help of pharmacological, biochemical, morphological, and molecular approaches, we provide evidence that the peripheral-type benzodiazepine receptor mediates the intramitochondrial cholesterol transport and the subsequent adrenal, gonadal, placental, and brain steroid biosynthesis.Entities:
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Year: 1998 PMID： 9452136 DOI： 10.3181/00379727-217-44215
Source DB: PubMed Journal: Proc Soc Exp Biol Med ISSN： 0037-9727