Literature DB >> 9438016

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

M S Wolfe1, M Citron, T S Diehl, W Xia, I O Donkor, D J Selkoe.   

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Year:  1998        PMID: 9438016     DOI: 10.1021/jm970621b

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


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  38 in total

1.  Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein.

Authors:  S F Lichtenthaler; R Wang; H Grimm; S N Uljon; C L Masters; K Beyreuther
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-16       Impact factor: 11.205

Review 2.  Spotlight on BACE: the secretases as targets for treatment in Alzheimer disease.

Authors:  C Dingwall
Journal:  J Clin Invest       Date:  2001-11       Impact factor: 14.808

Review 3.  Presenilin, Notch, and the genesis and treatment of Alzheimer's disease.

Authors:  D J Selkoe
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-25       Impact factor: 11.205

Review 4.  Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease.

Authors:  Dennis J Selkoe
Journal:  J Clin Invest       Date:  2002-11       Impact factor: 14.808

Review 5.  Cellular mechanisms of γ-secretase substrate selection, processing and toxicity.

Authors:  Gael Barthet; Anastasios Georgakopoulos; Nikolaos K Robakis
Journal:  Prog Neurobiol       Date:  2012-05-20       Impact factor: 11.685

Review 6.  Therapeutic approaches to modulating Notch signaling: current challenges and future prospects.

Authors:  Casper Groth; Mark E Fortini
Journal:  Semin Cell Dev Biol       Date:  2012-01-30       Impact factor: 7.727

Review 7.  Expanding the polypeptide backbone: hydrogen-bonded conformations in hybrid polypeptides containing the higher homologues of alpha-amino acids.

Authors:  Sunanda Chatterjee; Rituparna Sinha Roy; P Balaram
Journal:  J R Soc Interface       Date:  2007-08-22       Impact factor: 4.118

Review 8.  Unraveling the complexity of γ-secretase.

Authors:  Michael S Wolfe
Journal:  Semin Cell Dev Biol       Date:  2020-01-21       Impact factor: 7.727

9.  Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP.

Authors:  Casper Groth; W Gregory Alvord; Octavio A Quiñones; Mark E Fortini
Journal:  Mol Pharmacol       Date:  2010-01-11       Impact factor: 4.436

10.  Distinct pharmacological effects of inhibitors of signal peptide peptidase and gamma-secretase.

Authors:  Toru Sato; Kuppanna Ananda; Cathy I Cheng; Eric J Suh; Saravanakumar Narayanan; Michael S Wolfe
Journal:  J Biol Chem       Date:  2008-10-01       Impact factor: 5.157

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