Literature DB >> 9420302

Hepatitis G virus encodes protease activities which can effect processing of the virus putative nonstructural proteins.

A S Belyaev1, S Chong, A Novikov, A Kongpachith, F R Masiarz, M Lim, J P Kim.   

Abstract

The genome of a recently identified virus, hepatitis G virus (HGV), shows considerable homology to hepatitis C virus (HCV). Two HGV proteases similar to nonstructural proteins NS2 and NS3 of HCV were identified, and their cleavage site specificity was investigated. Amino acids essential for the protease activities were determined by mutation analysis. NS4A of HGV was demonstrated to be a cofactor for NS3-mediated proteolysis, with a region critical for activity residing between Leu1561, and Ala1598.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9420302      PMCID： PMC109451     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  32 in total

1.  Complex formation between the NS3 serine-type proteinase of the hepatitis C virus and NS4A and its importance for polyprotein maturation.

Authors:  R Bartenschlager; V Lohmann; T Wilkinson; J O Koch
Journal:  J Virol       Date:  1995-12       Impact factor: 5.103

2.  Alphabet of hepatitis viruses.

Authors:  A J Zuckerman
Journal:  Lancet       Date:  1996-03-02       Impact factor: 79.321

3.  Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing.

Authors:  Y Tanji; M Hijikata; S Satoh; T Kaneko; K Shimotohno
Journal:  J Virol       Date:  1995-03       Impact factor: 5.103

4.  Hepatitis C virus-encoded NS2-3 protease: cleavage-site mutagenesis and requirements for bimolecular cleavage.

Authors:  K E Reed; A Grakoui; C M Rice
Journal:  J Virol       Date:  1995-07       Impact factor: 5.103

5.  Enzymatic characterization of purified NS3 serine proteinase of hepatitis C virus expressed in Escherichia coli.

Authors:  A Mori; K Yamada; J Kimura; T Koide; S Yuasa; E Yamada; T Miyamura
Journal:  FEBS Lett       Date:  1996-01-02       Impact factor: 4.124

6.  Isolation of novel virus-like sequences associated with human hepatitis.

Authors:  J N Simons; T P Leary; G J Dawson; T J Pilot-Matias; A S Muerhoff; G G Schlauder; S M Desai; I K Mushahwar
Journal:  Nat Med       Date:  1995-06       Impact factor: 53.440

7.  Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent.

Authors:  J Linnen; J Wages; Z Y Zhang-Keck; K E Fry; K Z Krawczynski; H Alter; E Koonin; M Gallagher; M Alter; S Hadziyannis; P Karayiannis; K Fung; Y Nakatsuji; J W Shih; L Young; M Piatak; C Hoover; J Fernandez; S Chen; J C Zou; T Morris; K C Hyams; S Ismay; J D Lifson; G Hess; S K Foung; H Thomas; D Bradley; H Margolis; J P Kim
Journal:  Science       Date:  1996-01-26       Impact factor: 47.728

8.  Molecular and serologic analysis in the transmission of the GB hepatitis agents.

Authors:  G G Schaluder; G J Dawson; J N Simons; T J Pilot-Matias; R A Gutierrez; C A Heynen; M F Knigge; G S Kurpiewski; S L Buijk; T P Leary
Journal:  J Med Virol       Date:  1995-05       Impact factor: 2.327

9.  Identification of the sequence on NS4A required for enhanced cleavage of the NS5A/5B site by hepatitis C virus NS3 protease.

Authors:  Y Shimizu; K Yamaji; Y Masuho; T Yokota; H Inoue; K Sudo; S Satoh; K Shimotohno
Journal:  J Virol       Date:  1996-01       Impact factor: 5.103

10.  In vitro studies on the activation of the hepatitis C virus NS3 proteinase by the NS4A cofactor.

Authors:  J O Koch; V Lohmann; U Herian; R Bartenschlager
Journal:  Virology       Date:  1996-07-01       Impact factor: 3.616
View more
  19 in total

1.  Prokaryotical expression of structural and non-structural proteins of hepatitis G virus.

Authors:  N S Xia; H J Yang; J Zhang; C Q Lin; Y B Wang; J Wang; M Y Zhan; M Ng
Journal:  World J Gastroenterol       Date:  2001-10       Impact factor: 5.742

2.  Characterization of the hepatitis C virus NS2/3 processing reaction by using a purified precursor protein.

Authors:  M Pallaoro; A Lahm; G Biasiol; M Brunetti; C Nardella; L Orsatti; F Bonelli; S Orrù; F Narjes; C Steinkühler
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

3.  Characterization of a peptide domain within the GB virus C envelope glycoprotein (E2) that inhibits HIV replication.

Authors:  Jinhua Xiang; James H McLinden; Thomas M Kaufman; Emma L Mohr; Nirjal Bhattarai; Qing Chang; Jack T Stapleton
Journal:  Virology       Date:  2012-05-16       Impact factor: 3.616

Review 4.  Role of GB virus C in modulating HIV disease.

Authors:  Carolynne Schwarze-Zander; Jason T Blackard; Juergen K Rockstroh
Journal:  Expert Rev Anti Infect Ther       Date:  2012-05       Impact factor: 5.091

5.  Structural constraints on RNA virus evolution.

Authors:  P Simmonds; D B Smith
Journal:  J Virol       Date:  1999-07       Impact factor: 5.103

6.  Characterization of an immunodominant antigenic site on GB virus C glycoprotein E2 that is involved in cell binding.

Authors:  James H McLinden; Thomas M Kaufman; Jinhua Xiang; Qing Chang; Donna Klinzman; Alfred M Engel; Georg Hess; Urban Schmidt; Michael Houghton; Jack T Stapleton
Journal:  J Virol       Date:  2006-10-11       Impact factor: 5.103

7.  RNA-Stimulated ATPase and RNA helicase activities and RNA binding domain of hepatitis G virus nonstructural protein 3.

Authors:  Y Gwack; H Yoo; I Song; J Choe; J H Han
Journal:  J Virol       Date:  1999-04       Impact factor: 5.103

8.  Virus-specific cofactor requirement and chimeric hepatitis C virus/GB virus B nonstructural protein 3.

Authors:  N Butkiewicz; N Yao; W Zhong; J Wright-Minogue; P Ingravallo; R Zhang; J Durkin; D N Standring; B M Baroudy; D V Sangar; S M Lemon; J Y Lau; Z Hong
Journal:  J Virol       Date:  2000-05       Impact factor: 5.103

9.  Identification of GBV-D, a novel GB-like flavivirus from old world frugivorous bats (Pteropus giganteus) in Bangladesh.

Authors:  Jonathan H Epstein; Phenix-Lan Quan; Thomas Briese; Craig Street; Omar Jabado; Sean Conlan; Shahneaz Ali Khan; Dawn Verdugo; M Jahangir Hossain; Stephen K Hutchison; Michael Egholm; Stephen P Luby; Peter Daszak; W Ian Lipkin
Journal:  PLoS Pathog       Date:  2010-07-01       Impact factor: 6.823

Review 10.  GB virus type C interactions with HIV: the role of envelope glycoproteins.

Authors:  Emma L Mohr; Jack T Stapleton
Journal:  J Viral Hepat       Date:  2009-09-15       Impact factor: 3.728
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.