Literature DB >> 9384534

New insights from spectroscopy into the structure/function relationships of lipoxygenases.

E I Solomon1, J Zhou, F Neese, E G Pavel.   

Abstract

Spectroscopic properties of the redox-active iron in the active site of plant and mammalian lipoxygenases can now be combined with recent crystal structure determinations to obtain new insights into lipoxygenase reaction mechanisms.

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Year:  1997        PMID： 9384534     DOI： 10.1016/s1074-5521(97)90113-7

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  28 in total

Review 1.  The enzymology and pharmacology of 5-lipoxygenase and 5-lipoxygenase activating protein.

Authors:  R L Bell; R R Harris
Journal:  Clin Rev Allergy Immunol       Date:  1999 Spring-Summer       Impact factor: 8.667

2.  Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase.

Authors:  Diane K Luci; J Brian Jameson; Adam Yasgar; Giovanni Diaz; Netra Joshi; Auric Kantz; Kate Markham; Steve Perry; Norine Kuhn; Jennifer Yeung; Edward H Kerns; Lena Schultz; Michael Holinstat; Jerry L Nadler; David A Taylor-Fishwick; Ajit Jadhav; Anton Simeonov; Theodore R Holman; David J Maloney
Journal:  J Med Chem       Date:  2014-01-06       Impact factor: 7.446

3.  Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

Authors:  Victor Kenyon; Ganesha Rai; Ajit Jadhav; Lena Schultz; Michelle Armstrong; J Brian Jameson; Steven Perry; Netra Joshi; James M Bougie; William Leister; David A Taylor-Fishwick; Jerry L Nadler; Michael Holinstat; Anton Simeonov; David J Maloney; Theodore R Holman
Journal:  J Med Chem       Date:  2011-07-08       Impact factor: 7.446

4.  Role of the Proximal Cysteine Hydrogen Bonding Interaction in Cytochrome P450 2B4 Studied by Cryoreduction, Electron Paramagnetic Resonance, and Electron-Nuclear Double Resonance Spectroscopy.

Authors:  Roman Davydov; Sangchoul Im; Muralidharan Shanmugam; William A Gunderson; Naw May Pearl; Brian M Hoffman; Lucy Waskell
Journal:  Biochemistry       Date:  2016-02-03       Impact factor: 3.162

5.  Continuous measurement of the lipoxygenase-catalyzed oxidation of unsaturated lipids using the monomolecular film technique.

Authors:  Abdelkarim Abousalham; Robert Verger
Journal:  Pharm Res       Date:  2006-08-24       Impact factor: 4.200

6.  Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.

Authors:  Joshua D Deschamps; Jeffrey T Gautschi; Stephanie Whitman; Tyler A Johnson; Nadine C Gassner; Phillip Crews; Theodore R Holman
Journal:  Bioorg Med Chem       Date:  2007-08-22       Impact factor: 3.641

7.  Substrate specificity effects of lipoxygenase products and inhibitors on soybean lipoxygenase-1.

Authors:  Aaron T Wecksler; Natalie K Garcia; Theodore R Holman
Journal:  Bioorg Med Chem       Date:  2009-08-08       Impact factor: 3.641

Review 8.  Structure/function correlations over binuclear non-heme iron active sites.

Authors:  Edward I Solomon; Kiyoung Park
Journal:  J Biol Inorg Chem       Date:  2016-07-01       Impact factor: 3.358

9.  Substrate specificity changes for human reticulocyte and epithelial 15-lipoxygenases reveal allosteric product regulation.

Authors:  Aaron T Wecksler; Victor Kenyon; Joshua D Deschamps; Theodore R Holman
Journal:  Biochemistry       Date:  2008-06-21       Impact factor: 3.162

10.  Substrate activation for O2 reactions by oxidized metal centers in biology.

Authors:  Monita Y M Pau; John D Lipscomb; Edward I Solomon
Journal:  Proc Natl Acad Sci U S A       Date:  2007-11-14       Impact factor: 11.205
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