| Literature DB >> 9377122 |
H Norrgren1, S Marquina, T Leitner, P Aaby, M Melbye, A G Poulsen, O Larsen, F Dias, D Escanilla, S Andersson, J Albert, A Nauclér.
Abstract
The purpose of this study was to document which genetic subtypes of HIV-2 are present in Guinea-Bissau and to investigate whether asymptomatic HIV-2 carriers and AIDS patients carry distinct genetic variants. A secondary aim was to correlate proviral DNA load to clinical and immunologic status of the patients. Thirty-eight asymptomatic HIV-2 carriers and 11 AIDS patients from Bissau, Guinea-Bissau were included in a cross-sectional study in which HIV-2 env V3 sequences, HIV-2 DNA load, and CD4-positive (CD4+) lymphocyte counts were determined. Phylogenetic analyses showed that all investigated subjects carried subtype A HIV-2 variants and that the sequences from AIDS patients and asymptomatic carriers did not form distinct subclusters in the tree. As expected, patients with AIDS had significantly higher median HIV-2 DNA load than did asymptomatic carriers (4.6 vs. 2.0 log10 HIV-2 DNA copies/10(6) CD4+ lymphocytes). Our study indicates that the HIV-2 epidemic in Guinea-Bissau is almost exclusively caused by subtype A HIV-2 variants and that the HIV-2 infections among the asymptomatic carriers and AIDS cases included in the study do not have distinct epidemiologic histories.Entities:
Keywords: Acquired Immunodeficiency Syndrome; Africa; Africa South Of The Sahara; Demographic Factors; Developing Countries; Diseases; Guinea-bissau; Hiv; Hiv Infections; Measurement; Population; Population Characteristics; Portuguese Speaking Africa; Prevalence; Research Methodology; Research Report; Urban Population; Viral Diseases; Western Africa
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Year: 1997 PMID： 9377122 DOI： 10.1097/00042560-199709010-00005
Source DB: PubMed Journal: J Acquir Immune Defic Syndr Hum Retrovirol ISSN： 1077-9450