Literature DB >> 9889242

Quantitation of human immunodeficiency virus type 2 DNA in peripheral blood mononuclear cells by using a quantitative-competitive PCR assay.

P Gomes1, N C Taveira, J M Pereira, F Antunes, M O Ferreira, M H Lourenço.   

Abstract

A new quantitative-competitive PCR-based human immunodeficiency virus type 2 (HIV-2) proviral DNA assay (QC-PCR) was developed and used to determine the proviral load in HIV-2-infected individuals. Proviral load varied considerably, with means of 1,831 copies per 10(6) peripheral blood mononuclear cells for asymptomatic subjects (n = 19) and 2,587 for AIDS patients (n = 2). HIV-2 viral and proviral loads also varied significantly over time in asymptomatic patients. These data suggest that a high level of virus replication occurs throughout the asymptomatic phase of HIV-2 infection.

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Year:  1999        PMID： 9889242      PMCID： PMC84340     

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  21 in total

1.  Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in human immunodeficiency virus type 1-infected individuals.

Authors:  R I Connor; H Mohri; Y Cao; D D Ho
Journal:  J Virol       Date:  1993-04       Impact factor: 5.103

2.  Autologous neutralizing antibodies prevail in HIV-2 but not in HIV-1 infection.

Authors:  E Björling; G Scarlatti; A von Gegerfelt; J Albert; G Biberfeld; F Chiodi; E Norrby; E M Fenyö
Journal:  Virology       Date:  1993-03       Impact factor: 3.616

3.  Genetic diversity of human immunodeficiency virus type 2: evidence for distinct sequence subtypes with differences in virus biology.

Authors:  F Gao; L Yue; D L Robertson; S C Hill; H Hui; R J Biggar; A E Neequaye; T M Whelan; D D Ho; G M Shaw
Journal:  J Virol       Date:  1994-11       Impact factor: 5.103

4.  Changes in plasma HIV-1 RNA and CD4+ lymphocyte counts and the risk of progression to AIDS. Veterans Affairs Cooperative Study Group on AIDS.

Authors:  W A O'Brien; P M Hartigan; D Martin; J Esinhart; A Hill; S Benoit; M Rubin; M S Simberkoff; J D Hamilton
Journal:  N Engl J Med       Date:  1996-02-15       Impact factor: 91.245

5.  HIV type 2 proviral load measured by quantitative polymerase chain reaction correlates with CD4+ lymphopenia in HIV type 2-infected individuals.

Authors:  N Berry; K Ariyoshi; O Jobe; P T Ngum; T Corrah; A Wilkins; H Whittle; R Tedder
Journal:  AIDS Res Hum Retroviruses       Date:  1994-08       Impact factor: 2.205

6.  Reduced rate of disease development after HIV-2 infection as compared to HIV-1.

Authors:  R Marlink; P Kanki; I Thior; K Travers; G Eisen; T Siby; I Traore; C C Hsieh; M C Dia; E H Gueye
Journal:  Science       Date:  1994-09-09       Impact factor: 47.728

7.  A community-based study of human immunodeficiency virus type 2 provirus load in rural village in West Africa.

Authors:  K Ariyoshi; N Berry; A Wilkins; D Ricard; P Aaby; A Nauclér; P T Ngom; O Jobe; S Jaffar; F Dias; R S Tedder; H Whittle
Journal:  J Infect Dis       Date:  1996-01       Impact factor: 5.226

8.  Prognosis in HIV-1 infection predicted by the quantity of virus in plasma.

Authors:  J W Mellors; C R Rinaldo; P Gupta; R M White; J A Todd; L A Kingsley
Journal:  Science       Date:  1996-05-24       Impact factor: 47.728

9.  Slower heterosexual spread of HIV-2 than HIV-1.

Authors:  P J Kanki; K U Travers; S MBoup; C C Hsieh; R G Marlink; A Gueye-NDiaye; T Siby; I Thior; M Hernandez-Avila; J L Sankalé
Journal:  Lancet       Date:  1994-04-16       Impact factor: 79.321

10.  Cellular and plasma viral load in patients infected with HIV-2.

Authors:  F Simon; S Matheron; C Tamalet; I Loussert-Ajaka; S Bartczak; J M Pépin; C Dhiver; E Gamba; C Elbim; J A Gastaut
Journal:  AIDS       Date:  1993-11       Impact factor: 4.177
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  9 in total

1.  Low plasma human immunodeficiency virus type 2 viral load is independent of proviral load: low virus production in vivo.

Authors:  S J Popper; A D Sarr; A Guèye-Ndiaye; S Mboup; M E Essex; P J Kanki
Journal:  J Virol       Date:  2000-02       Impact factor: 5.103

2.  Quantification of proviral load of human immunodeficiency virus type 2 subtypes A and B using real-time PCR.

Authors:  F Damond; D Descamps; I Farfara; J N Telles; S Puyeo; P Campa; A Leprêtre; S Matheron; F Brun-Vezinet; F Simon
Journal:  J Clin Microbiol       Date:  2001-12       Impact factor: 5.948

3.  Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection.

Authors:  Rui Soares; Russell Foxall; Adriana Albuquerque; Catarina Cortesão; Miguel Garcia; Rui M M Victorino; Ana E Sousa
Journal:  J Virol       Date:  2006-10-11       Impact factor: 5.103

4.  Cell-associated viral burden provides evidence of ongoing viral replication in aviremic HIV-2-infected patients.

Authors:  Rui S Soares; Rita Tendeiro; Russell B Foxall; António P Baptista; Rita Cavaleiro; Perpétua Gomes; Ricardo Camacho; Emília Valadas; Manuela Doroana; Margarida Lucas; Francisco Antunes; Rui M M Victorino; Ana E Sousa
Journal:  J Virol       Date:  2010-12-15       Impact factor: 5.103

5.  Plasma RNA viral load in human immunodeficiency virus type 2 subtype A and subtype B infections.

Authors:  Florence Damond; Marie Gueudin; Sophie Pueyo; Isabelle Farfara; David L Robertson; Diane Descamps; Geneviève Chène; Sophie Matheron; Pauline Campa; Françoise Brun-Vézinet; François Simon
Journal:  J Clin Microbiol       Date:  2002-10       Impact factor: 5.948

6.  Quantification of HIV-2 DNA in Whole Blood.

Authors:  Zsófia Szojka; Sara Karlson; Marianne Jansson; Patrik Medstrand
Journal:  Bio Protoc       Date:  2019-10-20

7.  Limited HIV-2 reservoirs in central-memory CD4 T-cells associated to CXCR6 co-receptor expression in attenuated HIV-2 infection.

Authors:  Assia Samri; Charlotte Charpentier; Mariama Sadjo Diallo; Mélanie Bertine; Sophie Even; Véronique Morin; Anne Oudin; Christophe Parizot; Gilles Collin; Anne Hosmalin; Rémi Cheynier; Rodolphe Thiébaut; Sophie Matheron; Fideline Collin; Rima Zoorob; Françoise Brun-Vézinet; Brigitte Autran
Journal:  PLoS Pathog       Date:  2019-05-16       Impact factor: 6.823

8.  Major depletion of plasmacytoid dendritic cells in HIV-2 infection, an attenuated form of HIV disease.

Authors:  Rita Cavaleiro; António P Baptista; Rui S Soares; Rita Tendeiro; Russell B Foxall; Perpétua Gomes; Rui M M Victorino; Ana E Sousa
Journal:  PLoS Pathog       Date:  2009-11-20       Impact factor: 6.823

9.  The role of the humoral immune response in the molecular evolution of the envelope C2, V3 and C3 regions in chronically HIV-2 infected patients.

Authors:  Pedro Borrego; José Maria Marcelino; Cheila Rocha; Manuela Doroana; Francisco Antunes; Fernando Maltez; Perpétua Gomes; Carlos Novo; Helena Barroso; Nuno Taveira
Journal:  Retrovirology       Date:  2008-09-08       Impact factor: 4.602
  9 in total

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