Literature DB >> 9342319

Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases.

J N Varghese1, P M Colman, A van Donkelaar, T J Blick, A Sahasrabudhe, J L McKimm-Breschkin.   

Abstract

The x-ray structure of a complex of sialic acid (Neu5Ac) with neuraminidase N9 subtype from A/tern/Australia/G70C/75 influenza virus at 4 degrees C has revealed the location of a second Neu5Ac binding site on the surface of the enzyme. At 18 degrees C, only the enzyme active site contains bound Neu5Ac. Neu5Ac binds in the second site in the chair conformation in a similar way to which it binds to hemagglutinin. The residues that interact with Neu5Ac at this second site are mostly conserved in avian strains, but not in human and swine strains, indicating that it has some as-yet-unknown biological function in birds.

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Year:  1997        PMID： 9342319      PMCID： PMC23599          DOI： 10.1073/pnas.94.22.11808

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  35 in total

1.  The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor.

Authors:  J N Varghese; J L McKimm-Breschkin; J B Caldwell; A A Kortt; P M Colman
Journal:  Proteins       Date:  1992-11

2.  Studies of the nonspecific hemagglutination inhibitor against influenza A2 virus (gamma inhibitor). III. Physicochemical properties of the gamma inhibitor.

Authors:  A SUGIURA; H SHIMOJO; C ENOMOTO
Journal:  Jpn J Exp Med       Date:  1961-06

3.  A new method for the purification of the influenza A virus neuraminidase.

Authors:  J L McKimm-Breschkin; J B Caldwell; R E Guthrie; A A Kortt
Journal:  J Virol Methods       Date:  1991-04       Impact factor: 2.014

4.  Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons.

Authors:  A Nicholls; K A Sharp; B Honig
Journal:  Proteins       Date:  1991

5.  Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants.

Authors:  W R Tulip; J N Varghese; A T Baker; A van Donkelaar; W G Laver; R G Webster; P M Colman
Journal:  J Mol Biol       Date:  1991-09-20       Impact factor: 5.469

Review 6.  Evolution and ecology of influenza A viruses.

Authors:  R G Webster; W J Bean; O T Gorman; T M Chambers; Y Kawaoka
Journal:  Microbiol Rev       Date:  1992-03

7.  N1 neuraminidase of influenza virus A/FPV/Rostock/34 has haemadsorbing activity.

Authors:  J Hausmann; E Kretzschmar; W Garten; H D Klenk
Journal:  J Gen Virol       Date:  1995-07       Impact factor: 3.891

8.  Red cells bound to influenza virus N9 neuraminidase are not released by the N9 neuraminidase activity.

Authors:  G M Air; W G Laver
Journal:  Virology       Date:  1995-08-01       Impact factor: 3.616

Review 9.  The molecular biology of influenza virus pathogenicity.

Authors:  H D Klenk; R Rott
Journal:  Adv Virus Res       Date:  1988       Impact factor: 9.937

10.  The 2.2 A resolution crystal structure of influenza B neuraminidase and its complex with sialic acid.

Authors:  W P Burmeister; R W Ruigrok; S Cusack
Journal:  EMBO J       Date:  1992-01       Impact factor: 11.598
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  58 in total

1.  Mutation signature in neuraminidase gene of avian influenza H9N2/G1 in Egypt.

Authors:  Zienab Mosaad; Abdelsatar Arafa; Hussein A Hussein; Mohamed A Shalaby
Journal:  Virusdisease       Date:  2017-05-23

2.  Mutation at residue 523 creates a second receptor binding site on human parainfluenza virus type 1 hemagglutinin-neuraminidase protein.

Authors:  Tatiana Bousse; Toru Takimoto
Journal:  J Virol       Date:  2006-09       Impact factor: 5.103

3.  Search for additional influenza virus to cell interactions.

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4.  Characterization of avian H9N2 influenza viruses from United Arab Emirates 2000 to 2003.

Authors:  U B Aamir; Ulrich Wernery; N Ilyushina; R G Webster
Journal:  Virology       Date:  2006-12-08       Impact factor: 3.616

Review 5.  Influenza Neuraminidase: Underrated Role in Receptor Binding.

Authors:  Feng Wen; Xiu-Feng Wan
Journal:  Trends Microbiol       Date:  2019-03-29       Impact factor: 17.079

6.  Multistructural hot spot characterization with FTProd.

Authors:  Lane Votapka; Rommie E Amaro
Journal:  Bioinformatics       Date:  2012-11-29       Impact factor: 6.937

7.  Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel.

Authors:  Xianghong Jing; Chunlong Ma; Yuki Ohigashi; Fernando A Oliveira; Theodore S Jardetzky; Lawrence H Pinto; Robert A Lamb
Journal:  Proc Natl Acad Sci U S A       Date:  2008-07-31       Impact factor: 11.205

8.  Adjustment of receptor-binding and neuraminidase substrate specificities in avian-human reassortant influenza viruses.

Authors:  Yulia Shtyrya; Larisa Mochalova; Galina Voznova; Irina Rudneva; Aleksandr Shilov; Nikolai Kaverin; Nicolai Bovin
Journal:  Glycoconj J       Date:  2008-07-26       Impact factor: 2.916

9.  Role of secondary sialic acid binding sites in influenza N1 neuraminidase.

Authors:  Jeffrey C Sung; Adam W Van Wynsberghe; Rommie E Amaro; Wilfred W Li; J Andrew McCammon
Journal:  J Am Chem Soc       Date:  2010-03-10       Impact factor: 15.419

10.  Molecular determinants of adaptation of highly pathogenic avian influenza H7N7 viruses to efficient replication in the human host.

Authors:  Emmie de Wit; Vincent J Munster; Debby van Riel; Walter E P Beyer; Guus F Rimmelzwaan; Thijs Kuiken; Albert D M E Osterhaus; Ron A M Fouchier
Journal:  J Virol       Date:  2009-11-25       Impact factor: 5.103
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