Literature DB >> 1438172

The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor.

J N Varghese1, J L McKimm-Breschkin, J B Caldwell, A A Kortt, P M Colman.   

Abstract

Crystallographic studies of neuraminidase-sialic acid complexes indicate that sialic acid is distorted on binding the enzyme. Three arginine residues on the enzyme interact with the carboxylate group of the sugar which is observed to be equatorial to the saccharide ring as a consequence of its distorted geometry. The glycosidic oxygen is positioned within hydrogen-bonding distance of Asp-151, implicating this residue in catalysis.

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Year:  1992        PMID： 1438172     DOI： 10.1002/prot.340140302

Source DB:  PubMed          Journal:  Proteins        ISSN： 0887-3585


  109 in total

1.  Analysis of inhibitor binding in influenza virus neuraminidase.

Authors:  B J Smith; P M Colman; M Von Itzstein; B Danylec; J N Varghese
Journal:  Protein Sci       Date:  2001-04       Impact factor: 6.725

2.  Antibody epitopes on the neuraminidase of a recent H3N2 influenza virus (A/Memphis/31/98).

Authors:  Upma Gulati; Chi-Ching Hwang; Lalitha Venkatramani; Shelly Gulati; Stephen J Stray; Janis T Lee; W Graeme Laver; Alexey Bochkarev; Adam Zlotnick; Gillian M Air
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3.  Sequencing of the ddl gene and modeling of the mutated D-alanine:D-alanine ligase in glycopeptide-dependent strains of Enterococcus faecium.

Authors:  Y Gholizadeh; M Prevost; F Van Bambeke; B Casadewall; P M Tulkens; P Courvalin
Journal:  Protein Sci       Date:  2001-04       Impact factor: 6.725

4.  Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases.

Authors:  J N Varghese; P M Colman; A van Donkelaar; T J Blick; A Sahasrabudhe; J L McKimm-Breschkin
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-28       Impact factor: 11.205

5.  Importance of neuraminidase active-site residues to the neuraminidase inhibitor resistance of influenza viruses.

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6.  Reduced susceptibility to all neuraminidase inhibitors of influenza H1N1 viruses with haemagglutinin mutations and mutations in non-conserved residues of the neuraminidase.

Authors:  Jennifer L McKimm-Breschkin; Janelle Williams; Susan Barrett; Kim Jachno; Mandy McDonald; Peter G Mohr; Takehiko Saito; Masato Tashiro
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Review 7.  Neuraminidase inhibitors for influenza B virus infection: efficacy and resistance.

Authors:  Andrew J Burnham; Tatiana Baranovich; Elena A Govorkova
Journal:  Antiviral Res       Date:  2013-09-04       Impact factor: 5.970

8.  Mutation effects of neuraminidases and their docking with ligands: a molecular dynamics and free energy calculation study.

Authors:  Zhiwei Yang; Gang Yang; Lijun Zhou
Journal:  J Comput Aided Mol Des       Date:  2013-11-12       Impact factor: 3.686

9.  Molecular basis of binding of the Plasmodium falciparum receptor BAEBL to erythrocyte receptor glycophorin C.

Authors:  Lubin Jiang; Sai Duriseti; Peter Sun; Louis H Miller
Journal:  Mol Biochem Parasitol       Date:  2009-06-27       Impact factor: 1.759

10.  Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase.

Authors:  J N Varghese; V C Epa; P M Colman
Journal:  Protein Sci       Date:  1995-06       Impact factor: 6.725
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