Literature DB >> 9335624

The effect of marker heterozygosity on the power to detect linkage disequilibrium.

J Ott1, D Rabinowitz.   

Abstract

The relationship between marker heterozygosity and the power to detect linkage disequilibrium is examined through the analysis of an example and through a simulation study. The analysis suggests that, despite the penalties for multiple testing incurred with multiple alleles, greater heterozygosity results in greater power. The results of the simulation study are in accord with those of the analysis.

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Year:  1997        PMID： 9335624      PMCID： PMC1208209     

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  5 in total

1.  On the relative importance of marker heterozygosity and intermarker distance in gene mapping.

Authors:  J D Terwilliger; Y Ding; J Ott
Journal:  Genomics       Date:  1992-08       Impact factor: 5.736

2.  The effect of combining alleles into electrophoretic classes on detecting linkage disequilibrium.

Authors:  E Zouros; G B Golding; T F MacKay
Journal:  Genetics       Date:  1977-03       Impact factor: 4.562

3.  The detection of linkage disequilibrium between closely linked markers: RFLPs at the AI-CIII apolipoprotein genes.

Authors:  E A Thompson; S Deeb; D Walker; A G Motulsky
Journal:  Am J Hum Genet       Date:  1988-01       Impact factor: 11.025

4.  The detection of linkage disequilibrium in molecular sequence data.

Authors:  R C Lewontin
Journal:  Genetics       Date:  1995-05       Impact factor: 4.562

5.  The sampling distribution of linkage disequilibrium.

Authors:  G B Golding
Journal:  Genetics       Date:  1984-09       Impact factor: 4.562
  5 in total
  19 in total

1.  Genetic analysis of case/control data using estimated haplotype frequencies: application to APOE locus variation and Alzheimer's disease.

Authors:  D Fallin; A Cohen; L Essioux; I Chumakov; M Blumenfeld; D Cohen; N J Schork
Journal:  Genome Res       Date:  2001-01       Impact factor: 9.043

2.  Power of linkage versus association analysis of quantitative traits, by use of variance-components models, for sibship data.

Authors:  P C Sham; S S Cherny; S Purcell; J K Hewitt
Journal:  Am J Hum Genet       Date:  2000-04-12       Impact factor: 11.025

3.  A coalescent approach to study linkage disequilibrium between single-nucleotide polymorphisms.

Authors:  S Zöllner; A von Haeseler
Journal:  Am J Hum Genet       Date:  2000-02       Impact factor: 11.025

4.  Spectrum of nonrandom associations between microsatellite loci on human chromosome 11p15.

Authors:  C Zapata; S Rodríguez; G Visedo; F Sacristán
Journal:  Genetics       Date:  2001-07       Impact factor: 4.562

5.  Heterozygosities and allelic frequencies of 811 dinucleotide-repeat marker loci in the Taiwanese population.

Authors:  Cheng-Hsin Lu; Cherry Guan-Ju Lin; Lichih Huang; Ling-Mei Wang; Lawrence Shih-Hsin Wu
Journal:  J Hum Genet       Date:  2004-05-19       Impact factor: 3.172

6.  Cross-Species Application of SNP Chips is Not Suitable for Identifying Runs of Homozygosity.

Authors:  Aaron B A Shafer; Joshua M Miller; Marty Kardos
Journal:  J Hered       Date:  2016-01-15       Impact factor: 2.645

7.  Allelic frequencies and heterozygosities of microsatellite markers covering the whole genome in the Korean.

Authors:  M-H Park; K-S Kim; H-J Lee; Y-M Cho; H-K Lee; K-S Park; D-J Shin; Y Jang; K-J Kim; J Jung; H-L Kim; B Oh; J-Y Lee
Journal:  J Hum Genet       Date:  2008-02-08       Impact factor: 3.172

8.  Association of haplotypes of inflammation-related genes with gastric preneoplastic lesions in African Americans and Caucasians.

Authors:  Jovanny Zabaleta; Maria C Camargo; Marylyn D Ritchie; Maria B Piazuelo; Rosa A Sierra; Stephen D Turner; Alberto Delgado; Elizabeth T H Fontham; Barbara G Schneider; Pelayo Correa; Augusto C Ochoa
Journal:  Int J Cancer       Date:  2011-02-01       Impact factor: 7.396

9.  Genome screens using linkage disequilibrium tests: optimal marker characteristics and feasibility.

Authors:  N H Chapman; E M Wijsman
Journal:  Am J Hum Genet       Date:  1998-12       Impact factor: 11.025

10.  Evolutionary process of a tetranucleotide microsatellite locus in Acipenseriformes.

Authors:  Zhao Jun Shao; Eric Rivals; Na Zhao; Sovan Lek; Jianbo Chang; Patrick Berrebi
Journal:  J Genet       Date:  2011-08       Impact factor: 1.166
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