Literature DB >> 9301333

Lac repressor genetic map in real space.

H C Pace1, M A Kercher, P Lu, P Markiewicz, J H Miller, G Chang, M Lewis.   

Abstract

Here, we present a graphic display of the phenotypes of more than 4000 single amino acid substitution mutations on the three-dimensional structure of the lac repressor tetramer bound to DNA. The genetic data and the X-ray diffraction studies contribute to define an allosteric mechanism and yield a visual demonstration of the importance of core or buried residues in protein structure.

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Year:  1997        PMID： 9301333     DOI： 10.1016/s0968-0004(97)01104-3

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  23 in total

1.  Fine-tuning function: correlation of hinge domain interactions with functional distinctions between LacI and PurR.

Authors:  Liskin Swint-Kruse; Christopher Larson; B Montgomery Pettitt; Kathleen Shive Matthews
Journal:  Protein Sci       Date:  2002-04       Impact factor: 6.725

2.  Accounting for human polymorphisms predicted to affect protein function.

Authors:  Pauline C Ng; Steven Henikoff
Journal:  Genome Res       Date:  2002-03       Impact factor: 9.043

3.  Predicting deleterious amino acid substitutions.

Authors:  P C Ng; S Henikoff
Journal:  Genome Res       Date:  2001-05       Impact factor: 9.043

4.  Testing computational prediction of missense mutation phenotypes: functional characterization of 204 mutations of human cystathionine beta synthase.

Authors:  Qiong Wei; Liqun Wang; Qiang Wang; Warren D Kruger; Roland L Dunbrack
Journal:  Proteins       Date:  2010-07

5.  SIFT: Predicting amino acid changes that affect protein function.

Authors:  Pauline C Ng; Steven Henikoff
Journal:  Nucleic Acids Res       Date:  2003-07-01       Impact factor: 16.971

6.  SIFT missense predictions for genomes.

Authors:  Robert Vaser; Swarnaseetha Adusumalli; Sim Ngak Leng; Mile Sikic; Pauline C Ng
Journal:  Nat Protoc       Date:  2015-12-03       Impact factor: 13.491

7.  "Cold-sensitive" mutants of the Lac repressor.

Authors:  Andrew Barker; Stefan Oehler; Benno Müller-Hill
Journal:  J Bacteriol       Date:  2006-12-15       Impact factor: 3.490

8.  A synthetic phage lambda regulatory circuit.

Authors:  Shota Atsumi; John W Little
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-29       Impact factor: 11.205

9.  Functional domains of the Bacillus subtilis transcription factor AraR and identification of amino acids important for nucleoprotein complex assembly and effector binding.

Authors:  Irina Saraiva Franco; Luís Jaime Mota; Cláudio Manuel Soares; Isabel de Sá-Nogueira
Journal:  J Bacteriol       Date:  2006-04       Impact factor: 3.490

10.  Structural analysis of lac repressor bound to allosteric effectors.

Authors:  Robert Daber; Steven Stayrook; Allison Rosenberg; Mitchell Lewis
Journal:  J Mol Biol       Date:  2007-04-19       Impact factor: 5.469
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