Literature DB >> 9294196

Calx, a Na-Ca exchanger gene of Drosophila melanogaster.

E M Schwarz1, S Benzer.   

Abstract

We have cloned Calx, a gene that encodes a Na-Ca exchanger of Drosophila melanogaster. Calx encodes two repeated motifs, Calx-alpha and Calx-beta, that overlap domains required for exchanger activity and regulation. Calx has multiple transcripts in adults, including at least one expressed in the retina. The Calx genomic locus comprises >/=35 kb between the Atpalpha and rudimentary-like genes in chromosomal region 93B. In Xenopus oocytes, microinjected Calx cRNA induces calcium uptake like that of its homolog, the 3Na+-1Ca2+ exchanger of mammalian heart. Implications of Calx-alpha motifs for the mechanism of Na-Ca exchange are discussed.

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Year:  1997        PMID： 9294196      PMCID： PMC23348          DOI： 10.1073/pnas.94.19.10249

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  43 in total

1.  Na+/Ca2+ exchanger in Drosophila: cloning, expression, and transport differences.

Authors:  A Ruknudin; C Valdivia; P Kofuji; W J Lederer; D H Schulze
Journal:  Am J Physiol       Date:  1997-07

2.  Isolation and structure of an arrestin gene from Drosophila.

Authors:  D P Smith; B H Shieh; C S Zuker
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

3.  P-element-mediated enhancer detection: an efficient method for isolating and characterizing developmentally regulated genes in Drosophila.

Authors:  C Wilson; R K Pearson; H J Bellen; C J O'Kane; U Grossniklaus; W J Gehring
Journal:  Genes Dev       Date:  1989-09       Impact factor: 11.361

4.  Expression of cardiac sarcolemmal Na+-Ca2+ exchange activity in Xenopus laevis oocytes.

Authors:  S Longoni; M J Coady; T Ikeda; K D Philipson
Journal:  Am J Physiol       Date:  1988-12

Review 5.  Intracellular calcium homeostasis.

Authors:  E Carafoli
Journal:  Annu Rev Biochem       Date:  1987       Impact factor: 23.643

6.  Tissue specificity and alternative splicing of the Na+/Ca2+ exchanger isoforms NCX1, NCX2, and NCX3 in rat.

Authors:  B D Quednau; D A Nicoll; K D Philipson
Journal:  Am J Physiol       Date:  1997-04

7.  The cardiac Na+-Ca2+ exchanger binds to the cytoskeletal protein ankyrin.

Authors:  Z P Li; E P Burke; J S Frank; V Bennett; K D Philipson
Journal:  J Biol Chem       Date:  1993-06-05       Impact factor: 5.157

Review 8.  Molecular and kinetic aspects of sodium-calcium exchange.

Authors:  K D Philipson; D A Nicoll
Journal:  Int Rev Cytol       Date:  1993

9.  Molecular considerations relevant to the mechanism of active transport.

Authors:  J Kyte
Journal:  Nature       Date:  1981-07-16       Impact factor: 49.962

10.  Regulation of cardiac Na(+)-Ca2+ exchanger by the endogenous XIP region.

Authors:  S Matsuoka; D A Nicoll; Z He; K D Philipson
Journal:  J Gen Physiol       Date:  1997-02       Impact factor: 4.086
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  52 in total

1.  A flagellar K(+)-dependent Na(+)/Ca(2+) exchanger keeps Ca(2+) low in sea urchin spermatozoa.

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Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-14       Impact factor: 11.205

Review 2.  The sodium/calcium exchanger family-SLC8.

Authors:  Beate D Quednau; Debora A Nicoll; Kenneth D Philipson
Journal:  Pflugers Arch       Date:  2003-05-07       Impact factor: 3.657

3.  Characterization and purification of a Na+/Ca2+ exchanger from an archaebacterium.

Authors:  Gabriel Mercado Besserer; Debora A Nicoll; Jeff Abramson; Kenneth D Philipson
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4.  Structural basis of the Ca2+ inhibitory mechanism of Drosophila Na+/Ca2+ exchanger CALX and its modification by alternative splicing.

Authors:  Mousheng Wu; Shuilong Tong; Jennifer Gonzalez; Vasanthi Jayaraman; John L Spudich; Lei Zheng
Journal:  Structure       Date:  2011-10-12       Impact factor: 5.006

5.  Restrained expression, a method to overproduce toxic membrane proteins by exploiting operator-repressor interactions.

Authors:  Anoop Narayanan; Marc Ridilla; Dinesh A Yernool
Journal:  Protein Sci       Date:  2011-01       Impact factor: 6.725

Review 6.  Multiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesis.

Authors:  Kevin Wilhelmsen; Sandy H M Litjens; Arnoud Sonnenberg
Journal:  Mol Cell Biol       Date:  2006-04       Impact factor: 4.272

7.  Full-length cardiac Na+/Ca2+ exchanger 1 protein is not phosphorylated by protein kinase A.

Authors:  Pimthanya Wanichawan; William E Louch; Kristin H Hortemo; Bjørg Austbø; Per Kristian Lunde; John D Scott; Ole M Sejersted; Cathrine R Carlson
Journal:  Am J Physiol Cell Physiol       Date:  2011-02-02       Impact factor: 4.249

Review 8.  20 years from NCX purification and cloning: milestones.

Authors:  Debora A Nicoll; Michela Ottolia; Joshua I Goldhaber; Kenneth D Philipson
Journal:  Adv Exp Med Biol       Date:  2013       Impact factor: 2.622

9.  Differential localization profile of Fras1/Frem proteins in epithelial basement membranes of newborn and adult mice.

Authors:  E Pavlakis; A K Makrygiannis; R Chiotaki; G Chalepakis
Journal:  Histochem Cell Biol       Date:  2008-06-18       Impact factor: 4.304

10.  Presynaptic calcium channel localization and calcium-dependent synaptic vesicle exocytosis regulated by the Fuseless protein.

Authors:  A Ashleigh Long; Eunju Kim; Hung-Tat Leung; Elvin Woodruff; Lingling An; R W Doerge; William L Pak; Kendal Broadie
Journal:  J Neurosci       Date:  2008-04-02       Impact factor: 6.167
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