| Literature DB >> 12734757 |
Beate D Quednau1, Debora A Nicoll, Kenneth D Philipson.
Abstract
The Na(+)/Ca(2+) exchanger gene family encompasses three distinct proteins, NCX1, NCX2, and NCX3, which mediate cellular Ca(2+) efflux and thus contribute to intracellular Ca(2+) homeostasis. NCX1 is expressed ubiquitously while NCX2 and NCX3 are limited to brain and skeletal muscle. NCX1 exchanges 3 extracellular Na(+) for 1 intracellular Ca(2+). In addition to transporting Na(+) and Ca(2+), NCX1 activity is also regulated by these cations. NCX1 is especially important in regulating cardiac contractility.Entities:
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Year: 2003 PMID： 12734757 DOI： 10.1007/s00424-003-1065-4
Source DB: PubMed Journal: Pflugers Arch ISSN： 0031-6768 Impact factor: 3.657