Literature DB >> 7511893

A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma.

K Sakai1, M Gofuku, Y Kitagawa, T Ogasawara, G Hirose, M Yamazaki, C S Koh, N Yanagisawa, L Steinman.   

Abstract

A hippocampal 38 kd autoantigen recognized by an autoantibody from the serum of a patient with paraneoplastic limbic encephalitis (PLE) and small cell lung carcinoma (SCLC) was isolated by screening a human hippocampal cDNA library. The 1,991-nucleotide ple21 clone was obtained and the deduced 350-residue protein encoded by the ple21 cDNA clone was found to be highly homologous to the neuron-specific RNA recognition motifs (RRMs)-containing proteins. The homologies were confined to the RRMs and the RRM connecting region. The presence of RRM in the antigenic protein may be important in the pathogenesis of SCLC-associated paraneoplastic neurologic syndrome.

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Year:  1994        PMID： 7511893     DOI： 10.1006/bbrc.1994.1358

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  19 in total

1.  Embryonic lethal abnormal vision-like RNA-binding proteins regulate neurite outgrowth and tau expression in PC12 cells.

Authors:  G E Aranda-Abreu; L Behar; S Chung; H Furneaux; I Ginzburg
Journal:  J Neurosci       Date:  1999-08-15       Impact factor: 6.167

2.  The RNA-binding protein HuD is required for GAP-43 mRNA stability, GAP-43 gene expression, and PKC-dependent neurite outgrowth in PC12 cells.

Authors:  C D Mobarak; K D Anderson; M Morin; A Beckel-Mitchener; S L Rogers; H Furneaux; P King; N I Perrone-Bizzozero
Journal:  Mol Biol Cell       Date:  2000-09       Impact factor: 4.138

3.  Complex formation of the neuron-specific ELAV-like Hu RNA-binding proteins.

Authors:  Katsumi Kasashima; Eiji Sakashita; Kuniaki Saito; Hiroshi Sakamoto
Journal:  Nucleic Acids Res       Date:  2002-10-15       Impact factor: 16.971

Review 4.  MRNA stability and the control of gene expression: implications for human disease.

Authors:  Elysia M Hollams; Keith M Giles; Andrew M Thomson; Peter J Leedman
Journal:  Neurochem Res       Date:  2002-10       Impact factor: 3.996

5.  The Elav-like proteins bind to AU-rich elements and to the poly(A) tail of mRNA.

Authors:  W J Ma; S Chung; H Furneaux
Journal:  Nucleic Acids Res       Date:  1997-09-15       Impact factor: 16.971

Review 6.  Embryonic lethal abnormal visual RNA-binding proteins involved in growth, differentiation, and posttranscriptional gene expression.

Authors:  D Antic; J D Keene
Journal:  Am J Hum Genet       Date:  1997-08       Impact factor: 11.025

7.  Two different RNA binding activities for the AU-rich element and the poly(A) sequence of the mouse neuronal protein mHuC.

Authors:  R Abe; E Sakashita; K Yamamoto; H Sakamoto
Journal:  Nucleic Acids Res       Date:  1996-12-15       Impact factor: 16.971

Review 8.  Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease.

Authors:  Stefanie Gerstberger; Markus Hafner; Manuel Ascano; Thomas Tuschl
Journal:  Adv Exp Med Biol       Date:  2014       Impact factor: 2.622

9.  A conserved family of elav-like genes in vertebrates.

Authors:  P J Good
Journal:  Proc Natl Acad Sci U S A       Date:  1995-05-09       Impact factor: 11.205

Review 10.  Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain.

Authors:  R B Darnell
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-14       Impact factor: 11.205
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