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Literature DB >> 9263408

Natural functions of bacterial multidrug transporters.

Abstract

Bacteria express several multidrug transporters that recognize structurally dissimilar toxic molecules and expel them from cells. These transporters may have evolved to protect bacteria from diverse environmental toxins or to transport specific physiological compounds with the ability to expel drugs being only a fortuitous side effect.

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Year: 1997 PMID： 9263408 DOI： 10.1016/S0966-842X(97)01064-0

Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 17.079

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Cited

35 in total

1. In vitro development of resistance to six quinolones in Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus.

Authors: M Boos; S Mayer; A Fischer; K Köhrer; S Scheuring; P Heisig; J Verhoef; A C Fluit; F J Schmitz
Journal: Antimicrob Agents Chemother Date: 2001-03 Impact factor: 5.191

9. Paradoxical enhancement of the activity of a bacterial multidrug transporter caused by substitutions of a conserved residue.

Authors: K A Klyachko; A A Neyfakh
Journal: J Bacteriol Date: 1998-06 Impact factor: 3.490

Review 10. Multidrug resistance in bacteria.

Authors: Hiroshi Nikaido
Journal: Annu Rev Biochem Date: 2009 Impact factor: 23.643

Natural functions of bacterial multidrug transporters.

1. In vitro development of resistance to six quinolones in Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus.

Review 2. Molecular properties of bacterial multidrug transporters.

Review 3. Efflux-mediated resistance to fluoroquinolones in gram-positive bacteria and the mycobacteria.

4. Analysis of membrane proteins in metagenomics: networks of correlated environmental features and protein families.

5. c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response.

6. No single irreplaceable acidic residues in the Escherichia coli secondary multidrug transporter MdfA.

7. A coordinated network of transporters with overlapping specificities provides a robust survival strategy.

8. The secondary multidrug/proton antiporter MdfA tolerates displacements of an essential negatively charged side chain.

9. Paradoxical enhancement of the activity of a bacterial multidrug transporter caused by substitutions of a conserved residue.

Review 10. Multidrug resistance in bacteria.