Literature DB >> 16855255

No single irreplaceable acidic residues in the Escherichia coli secondary multidrug transporter MdfA.

Nadejda Sigal1, Shahar Molshanski-Mor, Eitan Bibi.   

Abstract

The largest family of solute transporters (major facilitator superfamily [MFS]) includes proton-motive-force-driven secondary transporters. Several characterized MFS transporters utilize essential acidic residues that play a critical role in the energy-coupling mechanism during transport. Surprisingly, we show here that no single acidic residue plays an irreplaceable role in the Escherichia coli secondary multidrug transporter MdfA.

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Year:  2006        PMID： 16855255      PMCID： PMC1540044          DOI： 10.1128/JB.00422-06

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  31 in total

Review 1.  Inhibition of efflux pumps as a novel approach to combat drug resistance in bacteria.

Authors:  O Lomovskaya; W Watkins
Journal:  J Mol Microbiol Biotechnol       Date:  2001-04

Review 2.  MdfA, an interesting model protein for studying multidrug transport.

Authors:  E Bibi; J Adler; O Lewinson; R Edgar
Journal:  J Mol Microbiol Biotechnol       Date:  2001-04

3.  A broad-specificity multidrug efflux pump requiring a pair of homologous SMR-type proteins.

Authors:  D L Jack; M L Storms; J H Tchieu; I T Paulsen; M H Saier
Journal:  J Bacteriol       Date:  2000-04       Impact factor: 3.490

Review 4.  Molecular properties of bacterial multidrug transporters.

Authors:  M Putman; H W van Veen; W N Konings
Journal:  Microbiol Mol Biol Rev       Date:  2000-12       Impact factor: 11.056

Review 5.  Multidrug resistance mechanisms: drug efflux across two membranes.

Authors:  H I Zgurskaya; H Nikaido
Journal:  Mol Microbiol       Date:  2000-07       Impact factor: 3.501

Review 6.  Phylogeny of multidrug transporters.

Authors:  M H Saier; I T Paulsen
Journal:  Semin Cell Dev Biol       Date:  2001-06       Impact factor: 7.727

Review 7.  The kamikaze approach to membrane transport.

Authors:  H R Kaback; M Sahin-Tóth; A B Weinglass
Journal:  Nat Rev Mol Cell Biol       Date:  2001-08       Impact factor: 94.444

Review 8.  Promiscuity in multidrug recognition and transport: the bacterial MFS Mdr transporters.

Authors:  Oded Lewinson; Julia Adler; Nadejda Sigal; Eitan Bibi
Journal:  Mol Microbiol       Date:  2006-07       Impact factor: 3.501

9.  MdfA, an Escherichia coli multidrug resistance protein with an extraordinarily broad spectrum of drug recognition.

Authors:  R Edgar; E Bibi
Journal:  J Bacteriol       Date:  1997-04       Impact factor: 3.490

10.  Evidence for chloramphenicol/H+ antiport in Cmr (MdfA) system of Escherichia coli and properties of the antiporter.

Authors:  T Mine; Y Morita; A Kataoka; T Mizushima; T Tsuchiya
Journal:  J Biochem       Date:  1998-07       Impact factor: 3.387
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  13 in total

1.  Substrate-bound structure of the E. coli multidrug resistance transporter MdfA.

Authors:  Jie Heng; Yan Zhao; Ming Liu; Yue Liu; Junping Fan; Xianping Wang; Yongfang Zhao; Xuejun C Zhang
Journal:  Cell Res       Date:  2015-08-04       Impact factor: 25.617

Review 2.  Energy coupling mechanisms of MFS transporters.

Authors:  Xuejun C Zhang; Yan Zhao; Jie Heng; Daohua Jiang
Journal:  Protein Sci       Date:  2015-09-18       Impact factor: 6.725

3.  Structure and function analysis of CaMdr1p, a major facilitator superfamily antifungal efflux transporter protein of Candida albicans: identification of amino acid residues critical for drug/H+ transport.

Authors:  Ritu Pasrija; Dibyendu Banerjee; Rajendra Prasad
Journal:  Eukaryot Cell       Date:  2007-01-05

4.  The secondary multidrug/proton antiporter MdfA tolerates displacements of an essential negatively charged side chain.

Authors:  Nadejda Sigal; Nir Fluman; Shira Siemion; Eitan Bibi
Journal:  J Biol Chem       Date:  2009-01-07       Impact factor: 5.157

5.  Dissection of mechanistic principles of a secondary multidrug efflux protein.

Authors:  Nir Fluman; Christopher M Ryan; Julian P Whitelegge; Eitan Bibi
Journal:  Mol Cell       Date:  2012-07-26       Impact factor: 17.970

6.  Structural comparison of bacterial multidrug efflux pumps of the major facilitator superfamily.

Authors:  Indrika Ranaweera; Ugina Shrestha; K C Ranjana; Prathusha Kakarla; T Mark Willmon; Alberto J Hernandez; Mun Mun Mukherjee; Sharla R Barr; Manuel F Varela
Journal:  Trends Cell Mol Biol       Date:  2015

Review 7.  Multicomponent drug efflux complexes: architecture and mechanism of assembly.

Authors:  Helen I Zgurskaya
Journal:  Future Microbiol       Date:  2009-09       Impact factor: 3.165

8.  Insight into determinants of substrate binding and transport in a multidrug efflux protein.

Authors:  Kamela O Alegre; Stephanie Paul; Paola Labarbuta; Christopher J Law
Journal:  Sci Rep       Date:  2016-03-10       Impact factor: 4.379

9.  Proton-solute coupling mechanism of the maltose transporter from Saccharomyces cerevisiae.

Authors:  Ryan Henderson; Bert Poolman
Journal:  Sci Rep       Date:  2017-10-30       Impact factor: 4.379

10.  Rational mutational analysis of a multidrug MFS transporter CaMdr1p of Candida albicans by employing a membrane environment based computational approach.

Authors:  Khyati Kapoor; Mohd Rehan; Ajeeta Kaushiki; Ritu Pasrija; Andrew M Lynn; Rajendra Prasad
Journal:  PLoS Comput Biol       Date:  2009-12-24       Impact factor: 4.475
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