Literature DB >> 9261448

Chemokine receptor CCR5 genotype influences the kinetics of human immunodeficiency virus type 1 infection in human PBL-SCID mice.

G R Picchio1, R J Gulizia, D E Mosier.   

Abstract

Individuals homozygous for a 32-bp deletion (delta 32) in the CCR5 gene encoding the coreceptor for macrophage-tropic human immunodeficiency virus type 1 (HIV-1) are resistant to virus infection, and heterozygous individuals show some slowing of disease progression. The impact of the CCR5 genotype on HIV-1 infection was assessed in vitro and in the human PBL-SCID (hu-PBL-SCID) model. Cells and hu-PBL-SCID mice from CCR5 delta 32/delta 32 donors were resistant to infection with macrophage-tropic HIV-1 and showed slower replication of dual-tropic HIV-1. hu-PBL-SCID mice derived from CCR5 delta 32/+ heterozygotes showed delayed replication of macrophage-tropic HIV-1 despite a small and variable effect of heterozygosity on viral replication in vitro. The level of CCR5 expression appears to limit replication of macrophage-tropic and dual-tropic HIV-1 strains in vivo.

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Year:  1997        PMID： 9261448      PMCID： PMC192012     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  30 in total

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Authors:  H Deng; R Liu; W Ellmeier; S Choe; D Unutmaz; M Burkhart; P Di Marzio; S Marmon; R E Sutton; C M Hill; C B Davis; S C Peiper; T J Schall; D R Littman; N R Landau
Journal:  Nature       Date:  1996-06-20       Impact factor: 49.962

2.  HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.

Authors:  T Dragic; V Litwin; G P Allaway; S R Martin; Y Huang; K A Nagashima; C Cayanan; P J Maddon; R A Koup; J P Moore; W A Paxton
Journal:  Nature       Date:  1996-06-20       Impact factor: 49.962

Review 3.  Chemokines and HIV-1 second receptors. Confluence of two fields generates optimism in AIDS research.

Authors:  M P D'Souza; V A Harden
Journal:  Nat Med       Date:  1996-12       Impact factor: 53.440

4.  Multiple extracellular elements of CCR5 and HIV-1 entry: dissociation from response to chemokines.

Authors:  R E Atchison; J Gosling; F S Monteclaro; C Franci; L Digilio; I F Charo; M A Goldsmith
Journal:  Science       Date:  1996-12-13       Impact factor: 47.728

5.  HIV-1 infection in an individual homozygous for the CCR5 deletion allele.

Authors:  R Biti; R Ffrench; J Young; B Bennetts; G Stewart; T Liang
Journal:  Nat Med       Date:  1997-03       Impact factor: 53.440

6.  Macrophage tropism of human immunodeficiency virus type 1 and utilization of the CC-CKR5 coreceptor.

Authors:  C Cheng-Mayer; R Liu; N R Landau; L Stamatatos
Journal:  J Virol       Date:  1997-02       Impact factor: 5.103

7.  Macrophages and CD4+ T lymphocytes from two multiply exposed, uninfected individuals resist infection with primary non-syncytium-inducing isolates of human immunodeficiency virus type 1.

Authors:  R I Connor; W A Paxton; K E Sheridan; R A Koup
Journal:  J Virol       Date:  1996-12       Impact factor: 5.103

8.  Differential syncytium-inducing capacity of human immunodeficiency virus isolates: frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex.

Authors:  M Tersmette; R E de Goede; B J Al; I N Winkel; R A Gruters; H T Cuypers; H G Huisman; F Miedema
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9.  Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS.

Authors:  J A Levy; A D Hoffman; S M Kramer; J A Landis; J M Shimabukuro; L S Oshiro
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Authors:  A Granelli-Piperno; B Moser; M Pope; D Chen; Y Wei; F Isdell; U O'Doherty; W Paxton; R Koup; S Mojsov; N Bhardwaj; I Clark-Lewis; M Baggiolini; R M Steinman
Journal:  J Exp Med       Date:  1996-12-01       Impact factor: 14.307
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Authors:  J C de Quiros; W L Shupert; A C McNeil; J C Gea-Banacloche; M Flanigan; A Savage; L Martino; E E Weiskopf; H Imamichi; Y M Zhang; J Adelsburger; R Stevens; P M Murphy; P A Zimmerman; C W Hallahan; R T Davey; M Connors
Journal:  J Virol       Date:  2000-02       Impact factor: 5.103

2.  Counterpoint: Cord blood stem cell therapy for acquired immune deficiency syndrome.

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Authors:  E I Ginns; P St Jean; R A Philibert; M Galdzicka; P Damschroder-Williams; B Thiel; R T Long; L J Ingraham; H Dalwaldi; M A Murray; M Ehlert; S Paul; B G Remortel; A P Patel; M C Anderson; C Shaio; E Lau; I Dymarskaia; B M Martin; B Stubblefield; K M Falls; J P Carulli; T P Keith; C S Fann; L G Lacy; C R Allen; A M Hostetter; R C Elston; N J Schork; J A Egeland; S M Paul
Journal:  Proc Natl Acad Sci U S A       Date:  1998-12-22       Impact factor: 11.205

Review 4.  Human Immunodeficiency Virus Immune Cell Receptors, Coreceptors, and Cofactors: Implications for Prevention and Treatment.

Authors:  Andrew W Woodham; Joseph G Skeate; Adriana M Sanna; Julia R Taylor; Diane M Da Silva; Paula M Cannon; W Martin Kast
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Review 5.  Virus and target cell evolution in human immunodeficiency virus type 1 infection.

Authors:  D E Mosier
Journal:  Immunol Res       Date:  2000       Impact factor: 2.829

6.  Donor- and ligand-dependent differences in C-C chemokine receptor 5 reexpression.

Authors:  R Sabbe; G R Picchio; C Pastore; O Chaloin; O Hartley; R Offord; D E Mosier
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7.  Human immunodeficiency virus type 1 strains R5 and X4 induce different pathogenic effects in hu-PBL-SCID mice, depending on the state of activation/differentiation of human target cells at the time of primary infection.

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Journal:  J Virol       Date:  1999-08       Impact factor: 5.103

8.  The cell tropism of human immunodeficiency virus type 1 determines the kinetics of plasma viremia in SCID mice reconstituted with human peripheral blood leukocytes.

Authors:  G R Picchio; R J Gulizia; K Wehrly; B Chesebro; D E Mosier
Journal:  J Virol       Date:  1998-03       Impact factor: 5.103

9.  Determination of coreceptor usage of human immunodeficiency virus type 1 from patient plasma samples by using a recombinant phenotypic assay.

Authors:  V Trouplin; F Salvatori; F Cappello; V Obry; A Brelot; N Heveker; M Alizon; G Scarlatti; F Clavel; F Mammano
Journal:  J Virol       Date:  2001-01       Impact factor: 5.103

10.  TRIM5 gene polymorphisms in HIV-1-infected patients and healthy controls from Northeastern Brazil.

Authors:  Ronaldo Celerino da Silva; Antonio Victor Campos Coelho; Luiz Cláudio Arraes; Lucas André Cavalcanti Brandão; Sergio Crovella; Rafael Lima Guimarães
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  10 in total

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