Literature DB >> 10644376

Resistance to replication of human immunodeficiency virus challenge in SCID-Hu mice engrafted with peripheral blood mononuclear cells of nonprogressors is mediated by CD8(+) T cells and associated with a proliferative response to p24 antigen.

J C de Quiros1, W L Shupert, A C McNeil, J C Gea-Banacloche, M Flanigan, A Savage, L Martino, E E Weiskopf, H Imamichi, Y M Zhang, J Adelsburger, R Stevens, P M Murphy, P A Zimmerman, C W Hallahan, R T Davey, M Connors.   

Abstract

High levels of resistance to challenge with human immunodeficiency virus type 1 SF162 were observed in animals engrafted with peripheral blood mononuclear cells of four long-term nonprogressors (LTNPs). Resistance was abrogated by depletion of CD8(+) T cells in vivo and was observed only in LTNPs with proliferative responses to p24. In a subgroup of nonprogressors, CD8(+) T cells mediated restriction of challenge viruses, and this response was associated with strong proliferative responses to p24 antigen.

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Year:  2000        PMID： 10644376      PMCID： PMC111681          DOI： 10.1128/jvi.74.4.2023-2028.2000

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  36 in total

1.  Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia.

Authors:  E S Rosenberg; J M Billingsley; A M Caliendo; S L Boswell; P E Sax; S A Kalams; B D Walker
Journal:  Science       Date:  1997-11-21       Impact factor: 47.728

2.  Even individuals considered as long-term nonprogressors show biological signs of progression after 10 years of human immunodeficiency virus infection.

Authors:  J J Lefrère; L Morand-Joubert; M Mariotti; H Bludau; B Burghoffer; J C Petit; F Roudot-Thoraval
Journal:  Blood       Date:  1997-08-01       Impact factor: 22.113

3.  Stability in controlling viral replication identifies long-term nonprogressors as a distinct subgroup among human immunodeficiency virus type 1-infected persons.

Authors:  M Vesanen; C E Stevens; P E Taylor; P Rubinstein; K Saksela
Journal:  J Virol       Date:  1996-12       Impact factor: 5.103

4.  Chemokine receptor CCR5 genotype influences the kinetics of human immunodeficiency virus type 1 infection in human PBL-SCID mice.

Authors:  G R Picchio; R J Gulizia; D E Mosier
Journal:  J Virol       Date:  1997-09       Impact factor: 5.103

5.  Neutralizing antibody responses to human immunodeficiency virus type 1 in primary infection and long-term-nonprogressive infection.

Authors:  A K Pilgrim; G Pantaleo; O J Cohen; L M Fink; J Y Zhou; J T Zhou; D P Bolognesi; A S Fauci; D C Montefiori
Journal:  J Infect Dis       Date:  1997-10       Impact factor: 5.226

6.  CD4+ but not CD8+ cells are essential for allorejection.

Authors:  N R Krieger; D P Yin; C G Fathman
Journal:  J Exp Med       Date:  1996-11-01       Impact factor: 14.307

7.  Lack of consistency between five definitions of nonprogression in cohorts of HIV-infected seroconverters.

Authors:  S A Strathdee; P J Veugelers; K A Page-Shafer; A McNulty; A R Moss; M T Schechter; G J van Griensven; R A Coutinho
Journal:  AIDS       Date:  1996-08       Impact factor: 4.177

8.  Deletion of nef slows but does not prevent CD4-positive T-cell depletion in human immunodeficiency virus type 1-infected human-PBL-SCID mice.

Authors:  R J Gulizia; R G Collman; J A Levy; D Trono; D E Mosier
Journal:  J Virol       Date:  1997-05       Impact factor: 5.103

9.  Induction of a CD8+ cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell help.

Authors:  S R Bennett; F R Carbone; F Karamalis; J F Miller; W R Heath
Journal:  J Exp Med       Date:  1997-07-07       Impact factor: 14.307

10.  CD4+ T cell help impairs CD8+ T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity.

Authors:  C Kurts; F R Carbone; M Barnden; E Blanas; J Allison; W R Heath; J F Miller
Journal:  J Exp Med       Date:  1997-12-15       Impact factor: 14.307
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  18 in total

1.  Selecting peptides to optimize Th1 responses to an equine lentivirus using HLA-DR binding motifs and defined HIV-1 Th peptides.

Authors:  Darrilyn G Fraser; Robert H Mealey; Travis C McGuire
Journal:  Immunogenetics       Date:  2003-08-27       Impact factor: 2.846

Review 2.  Success and failure of the cellular immune response against HIV-1.

Authors:  Stephen A Migueles; Mark Connors
Journal:  Nat Immunol       Date:  2015-06       Impact factor: 25.606

3.  High-level HIV-1 viremia suppresses viral antigen-specific CD4(+) T cell proliferation.

Authors:  A C McNeil; W L Shupert; C A Iyasere; C W Hallahan; J A Mican; R T Davey; M Connors
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-20       Impact factor: 11.205

4.  Identification of broadly recognized, T helper 1 lymphocyte epitopes in an equine lentivirus.

Authors:  Darrilyn G Fraser; J Lindsay Oaks; Wendy C Brown; Travis C McGuire
Journal:  Immunology       Date:  2002-03       Impact factor: 7.397

5.  T-helper-cell proliferative responses to whole-killed human immunodeficiency virus type 1 (HIV-1) and p24 antigens of different clades in HIV-1-infected subjects vaccinated with HIV-1 immunogen (Remune).

Authors:  R B Moss; W Giermakowska; M R Wallace; J Savary; F Jensen; D J Carlo
Journal:  Clin Diagn Lab Immunol       Date:  2000-09

6.  A Murine Viral Outgrowth Assay to Detect Residual HIV Type 1 in Patients With Undetectable Viral Loads.

Authors:  Kelly A Metcalf Pate; Christopher W Pohlmeyer; Victoria E Walker-Sperling; Jeremy B Foote; Kevin M Najarro; Catherine G Cryer; Maria Salgado; Lucio Gama; Elizabeth L Engle; Erin N Shirk; Suzanne E Queen; Stanley Chioma; Meghan S Vermillion; Brandon Bullock; Ming Li; Claire E Lyons; Robert J Adams; M Christine Zink; Janice E Clements; Joseph L Mankowski; Joel N Blankson
Journal:  J Infect Dis       Date:  2015-04-15       Impact factor: 5.226

7.  Diminished proliferation of human immunodeficiency virus-specific CD4+ T cells is associated with diminished interleukin-2 (IL-2) production and is recovered by exogenous IL-2.

Authors:  Christiana Iyasere; John C Tilton; Alison J Johnson; Souheil Younes; Bader Yassine-Diab; Rafick-Pierre Sekaly; William W Kwok; Stephen A Migueles; Alisha C Laborico; W Lesley Shupert; Claire W Hallahan; Richard T Davey; Mark Dybul; Susan Vogel; Julia Metcalf; Mark Connors
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103

Review 8.  Effector mechanisms in HIV-1 infected elite controllers: highly active immune responses?

Authors:  Joel N Blankson
Journal:  Antiviral Res       Date:  2009-09-04       Impact factor: 5.970

9.  The interplay between the X-DING-CD4, IFN-α and IL-8 gene activity in quiescent and mitogen- or HIV-1-exposed PBMCs from HIV-1 elite controllers, AIDS progressors and HIV-negative controls.

Authors:  Rakhee Sachdeva; Rasheda Y Shilpi; Malgorzata Simm
Journal:  Innate Immun       Date:  2013-06-10       Impact factor: 2.680

10.  Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control.

Authors:  Stephen A Migueles; Christine M Osborne; Cassandra Royce; Alex A Compton; Rohan P Joshi; Kristin A Weeks; Julia E Rood; Amy M Berkley; Jonah B Sacha; Nancy A Cogliano-Shutta; Margaret Lloyd; Gregg Roby; Richard Kwan; Mary McLaughlin; Sara Stallings; Catherine Rehm; Marie A O'Shea; JoAnn Mican; Beverly Z Packard; Akira Komoriya; Sarah Palmer; Ann P Wiegand; Frank Maldarelli; John M Coffin; John W Mellors; Claire W Hallahan; Dean A Follman; Mark Connors
Journal:  Immunity       Date:  2008-12-08       Impact factor: 31.745
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