Literature DB >> 6206563

Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS.

J A Levy, A D Hoffman, S M Kramer, J A Landis, J M Shimabukuro, L S Oshiro.   

Abstract

Infectious retroviruses have been detected in 22 of 45 randomly selected patients with acquired immune deficiency syndrome (AIDS) and in other individuals from San Francisco. The AIDS-associated retroviruses (ARV) studied in detail had a type D morphology, Mg2+-dependent reverse transcriptase, and cytopathic effects on lymphocytes. The viruses can be propagated in an established adult human T cell line, HUT-78. They cross-react with antiserum to the lymphadenopathy-associated retrovirus isolated from AIDS patients in France. Antibodies to ARV were found in all 86 AIDS patients and in a high percentage of 88 other homosexual men in San Francisco. This observation indicates the widespread presence of these lymphocytopathic retroviruses and their close association with AIDS.

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Year:  1984        PMID： 6206563     DOI： 10.1126/science.6206563

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  342 in total

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