Literature DB >> 9253404

Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation.

A Lavie, I R Vetter, M Konrad, R S Goody, J Reinstein, I Schlichting.   

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Year:  1997        PMID: 9253404     DOI: 10.1038/nsb0897-601

Source DB:  PubMed          Journal:  Nat Struct Biol        ISSN: 1072-8368


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  19 in total

1.  Phosphorylation of thymidine and AZT in heart mitochondria: elucidation of a novel mechanism of AZT cardiotoxicity.

Authors:  Edward E McKee; Alice T Bentley; Matthew Hatch; Joel Gingerich; Delia Susan-Resiga
Journal:  Cardiovasc Toxicol       Date:  2004       Impact factor: 3.231

2.  3'-Azido-3'-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria.

Authors:  Matthew D Lynx; Edward E McKee
Journal:  Biochem Pharmacol       Date:  2006-04-25       Impact factor: 5.858

Review 3.  Synthesis of nucleoside phosphate and phosphonate prodrugs.

Authors:  Ugo Pradere; Ethel C Garnier-Amblard; Steven J Coats; Franck Amblard; Raymond F Schinazi
Journal:  Chem Rev       Date:  2014-08-21       Impact factor: 60.622

4.  3'-Azido-3'-deoxythymidine (AZT) mediates cross-resistance to nucleoside analogs in the case of AZT-resistant human immunodeficiency virus type 1 variants.

Authors:  E J Arts; M E Quiñones-Mateu; J L Albright; J P Marois; C Hough; Z Gu; M A Wainberg
Journal:  J Virol       Date:  1998-06       Impact factor: 5.103

5.  Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes.

Authors:  H Munier-Lehmann; A Chaffotte; S Pochet; G Labesse
Journal:  Protein Sci       Date:  2001-06       Impact factor: 6.725

6.  Structural basis for activation of alpha-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase.

Authors:  P Meyer; B Schneider; S Sarfati; D Deville-Bonne; C Guerreiro; J Boretto; J Janin; M Véron; B Canard
Journal:  EMBO J       Date:  2000-07-17       Impact factor: 11.598

7.  Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase.

Authors:  A Lavie; N Ostermann; R Brundiers; R S Goody; J Reinstein; M Konrad; I Schlichting
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-24       Impact factor: 11.205

8.  Effects of zidovudine and stavudine on mitochondrial DNA of differentiating 3T3-F442a cells are not associated with imbalanced deoxynucleotide pools.

Authors:  Matthew D Lynx; Darcy D LaClair; Edward E McKee
Journal:  Antimicrob Agents Chemother       Date:  2008-12-22       Impact factor: 5.191

9.  3'-Azido-3'-deoxythymidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: a possible mechanism of AZT hepatotoxicity.

Authors:  Matthew D Lynx; Alice T Bentley; Edward E McKee
Journal:  Biochem Pharmacol       Date:  2006-02-10       Impact factor: 5.858

10.  Structures of S. aureus thymidylate kinase reveal an atypical active site configuration and an intermediate conformational state upon substrate binding.

Authors:  Masayo Kotaka; Balvinder Dhaliwal; Jingshan Ren; Charles E Nichols; Richard Angell; Michael Lockyer; Alastair R Hawkins; David K Stammers
Journal:  Protein Sci       Date:  2006-03-07       Impact factor: 6.725

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