Literature DB >> 19104011

Effects of zidovudine and stavudine on mitochondrial DNA of differentiating 3T3-F442a cells are not associated with imbalanced deoxynucleotide pools.

Matthew D Lynx1, Darcy D LaClair, Edward E McKee.   

Abstract

To test whether zidovudine (3'-azido-3'-deoxythymidine) (AZT) inhibition of thymidine phosphorylation causes depletion of the TTP pool resulting in mitochondrial DNA depletion, 3T3-F442a cells were differentiated in the presence of AZT and analyzed to determine mitochondrial DNA content and deoxynucleotide levels. These results suggest that AZT toxicity may not be related to deoxynucleotide pool alterations.

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Year:  2008        PMID： 19104011      PMCID： PMC2650558          DOI： 10.1128/AAC.01115-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

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Journal:  J Biol Chem       Date:  2003-09-17       Impact factor: 5.157

10.  Effect of nucleoside and nucleotide reverse transcriptase inhibitors of HIV on endogenous nucleotide pools.

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Journal:  Antivir Ther       Date:  2008
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  5 in total

1.  Metabolism of deoxypyrimidines and deoxypyrimidine antiviral analogs in isolated brain mitochondria.

Authors:  Kathleen A McCann; David W Williams; Edward E McKee
Journal:  J Neurochem       Date:  2012-05-21       Impact factor: 5.372

2.  Mitochondrial complex I defect and increased fatty acid oxidation enhance protein lysine acetylation in the diabetic heart.

Authors:  Edwin J Vazquez; Jessica M Berthiaume; Vasudeva Kamath; Olisaemeka Achike; Elizabeth Buchanan; Monica M Montano; Margaret P Chandler; Masaru Miyagi; Mariana G Rosca
Journal:  Cardiovasc Res       Date:  2015-06-22       Impact factor: 10.787

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Authors:  Peter L Anderson; Joseph E Rower
Journal:  Clin Med Rev Ther       Date:  2010

4.  Kinetics of γH2AX and phospho-histone H3 following pulse treatment of TK6 cells provides insights into clastogenic activity.

Authors:  Steven M Bryce; Stephen D Dertinger; Jeffrey C Bemis
Journal:  Mutagenesis       Date:  2021-07-07       Impact factor: 2.954

5.  Generating Rho-0 Cells Using Mesenchymal Stem Cell Lines.

Authors:  Mercedes Fernández-Moreno; Tamara Hermida-Gómez; M Esther Gallardo; Andrea Dalmao-Fernández; Ignacio Rego-Pérez; Rafael Garesse; Francisco J Blanco
Journal:  PLoS One       Date:  2016-10-20       Impact factor: 3.240
  5 in total

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