Literature DB >> 923719

Methadone and brain development.

I S Zagon, P J McLaughlin.   

Abstract

The effect of maternally administered methadone hydrochloride (5 mg/kg) on brain development of offspring treated during gestation and/or lactation was studied in 21-day-old rats. Animals treated during gestation or lactation were the most severely affected, with reductions in brain weights (12% and 30%, respectively), and DNA values (50% and 34%, respectively) observed.

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Year:  1977        PMID： 923719     DOI： 10.1007/bf01918824

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

1.  Somatic growth effects of perinatal addiction.

Authors:  G S Wilson
Journal:  Addict Dis       Date:  1975

2.  A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.

Authors:  K BURTON
Journal:  Biochem J       Date:  1956-02       Impact factor: 3.857

3.  Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid.

Authors:  W C SCHNEIDER
Journal:  J Biol Chem       Date:  1945       Impact factor: 5.157

4.  The effects of different schedules of methadone treatment on rat brain development.

Authors:  I S Zagon; P J McLaughlin
Journal:  Exp Neurol       Date:  1977-09       Impact factor: 5.330

5.  Congenital malformations of the central nervous system produced by narcotic analgesics in the hamster.

Authors:  W F Geber; L C Schramm
Journal:  Am J Obstet Gynecol       Date:  1975-12-01       Impact factor: 8.661

6.  Teratogenic activity of methadone hydrochloride in mouse and chick embryos.

Authors:  A Jurand
Journal:  J Embryol Exp Morphol       Date:  1973-10

7.  Growth and development of the brain and spinal cord of the guinea pig.

Authors:  J Dobbing; J Sands
Journal:  Brain Res       Date:  1970-01-06       Impact factor: 3.252

8.  Effect of chronic maternal methadone exposure on perinatal development.

Authors:  I S Zagon; P J McLaughlin
Journal:  Biol Neonate       Date:  1977

9.  Drug addiction in pregnancy and the neonate.

Authors:  G Blinick; R C Wallach; E Jerez; B D Ackerman
Journal:  Am J Obstet Gynecol       Date:  1976-05-15       Impact factor: 8.661

10.  Growth retardation in young mice treated with d1-methadone.

Authors:  M Crofford; A A Smith
Journal:  Science       Date:  1973-09-07       Impact factor: 47.728
  10 in total
  5 in total

Review 1.  Selective vulnerability of cerebellar granule neuroblasts and their progeny to drugs with abuse liability.

Authors:  Kurt F Hauser; Valeriya K Khurdayan; Robin J Goody; Avindra Nath; Alois Saria; James R Pauly
Journal:  Cerebellum       Date:  2003       Impact factor: 3.847

2.  Improved parameters of metabolic glycaemic and immune function and arterial stiffness with naltrexone implant therapy.

Authors:  Albert Stuart Reece
Journal:  BMJ Case Rep       Date:  2009-04-14

3.  Protracted analgesia in young and adult rats maternally exposed to methadone.

Authors:  I S Zagon; P J McLaughlin
Journal:  Experientia       Date:  1980-03-15

Review 4.  Opiate Drugs with Abuse Liability Hijack the Endogenous Opioid System to Disrupt Neuronal and Glial Maturation in the Central Nervous System.

Authors:  Kurt F Hauser; Pamela E Knapp
Journal:  Front Pediatr       Date:  2018-01-23       Impact factor: 3.418

5.  The effects of maternally administered methadone, buprenorphine and naltrexone on offspring: review of human and animal data.

Authors:  W O Farid; S A Dunlop; R J Tait; G K Hulse
Journal:  Curr Neuropharmacol       Date:  2008-06       Impact factor: 7.363
  5 in total

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