Literature DB >> 4730446

Growth retardation in young mice treated with d1-methadone.

M Crofford, A A Smith.   

Abstract

Newborn mice injected daily for 6 weeks with dl-methadone in dosages of 2 to 8 milligrams per kilogram grew significantly more slowly than their saline-treated littermates. Litters given d-methadone, 4 milligrams per kilogram, grew normally. Concomitant treatment with naloxone, 10 milligrams per kilogram, prevented growth inhibition. A weight deficit persisted in mice observed 6 weeks after cessation of methadone treatment.

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Year:  1973        PMID： 4730446     DOI： 10.1126/science.181.4103.947

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  4 in total

Review 1.  Selective vulnerability of cerebellar granule neuroblasts and their progeny to drugs with abuse liability.

Authors:  Kurt F Hauser; Valeriya K Khurdayan; Robin J Goody; Avindra Nath; Alois Saria; James R Pauly
Journal:  Cerebellum       Date:  2003       Impact factor: 3.847

2.  Methadone and brain development.

Authors:  I S Zagon; P J McLaughlin
Journal:  Experientia       Date:  1977-11-15

3.  Effects of d1-methadone and morphine on developing chick embryo.

Authors:  A Jakubovic; E G McGeer; P L McGeer
Journal:  Experientia       Date:  1978-12-15

4.  Morphine inhibits Purkinje cell survival and dendritic differentiation in organotypic cultures of the mouse cerebellum.

Authors:  K F Hauser; J A Gurwell; C S Turbek
Journal:  Exp Neurol       Date:  1994-11       Impact factor: 5.330
  4 in total

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