Literature DB >> 9223516

Interaction of the UV-damaged DNA-binding protein with hepatitis B virus X protein is conserved among mammalian hepadnaviruses and restricted to transactivation-proficient X-insertion mutants.

D Sitterlin1, T H Lee, S Prigent, P Tiollais, J S Butel, C Transy.   

Abstract

We carried out a comparative analysis of several proposed host protein partners of the human hepatitis B virus X protein (HBx) using both the GAL4- and the LexA-based yeast two-hybrid system. We showed that the interaction of HBx with the UV-damaged DNA-binding protein (UVDDB) is positive in both yeast systems, detectable in cotransfected human cells, conserved by rodent hepadnavirus X proteins (known to transactivate in human cells), and tightly correlated with the transactivation proficiency of X-insertion mutants. Taken together, our results strongly suggest that UVDDB is involved in X-mediated transactivation.

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Year:  1997        PMID： 9223516      PMCID： PMC191882     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  39 in total

1.  Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication.

Authors:  R Colgrove; G Simon; D Ganem
Journal:  J Virol       Date:  1989-09       Impact factor: 5.103

2.  Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/threonine kinases.

Authors:  J C Cross; P Wen; W J Rutter
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-01       Impact factor: 11.205

3.  Proteasome complex as a potential cellular target of hepatitis B virus X protein.

Authors:  J Huang; J Kwong; E C Sun; T J Liang
Journal:  J Virol       Date:  1996-08       Impact factor: 5.103

4.  A novel genetic system to detect protein-protein interactions.

Authors:  S Fields; O Song
Journal:  Nature       Date:  1989-07-20       Impact factor: 49.962

5.  A truncated mutant (residues 58-140) of the hepatitis B virus X protein retains transactivation function.

Authors:  V Kumar; N Jayasuryan; R Kumar
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-28       Impact factor: 11.205

6.  Purification and characterization of a human protein that binds to damaged DNA.

Authors:  B J Hwang; G Chu
Journal:  Biochemistry       Date:  1993-02-16       Impact factor: 3.162

7.  The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks.

Authors:  H S Chen; S Kaneko; R Girones; R W Anderson; W E Hornbuckle; B C Tennant; P J Cote; J L Gerin; R H Purcell; R H Miller
Journal:  J Virol       Date:  1993-03       Impact factor: 5.103

8.  Hepatitis B virus X protein is not central to the viral life cycle in vitro.

Authors:  H E Blum; Z S Zhang; E Galun; F von Weizsäcker; B Garner; T J Liang; J R Wands
Journal:  J Virol       Date:  1992-02       Impact factor: 5.103

9.  Hepatitis B virus X protein interacts with a probable cellular DNA repair protein.

Authors:  T H Lee; S J Elledge; J S Butel
Journal:  J Virol       Date:  1995-02       Impact factor: 5.103

10.  HBx protein of hepatitis B virus interacts with the C-terminal portion of a novel human proteasome alpha-subunit.

Authors:  M Fischer; L Runkel; H Schaller
Journal:  Virus Genes       Date:  1995       Impact factor: 2.332
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  44 in total

1.  Hepatitis B virus X protein acts as a tumor promoter in development of diethylnitrosamine-induced preneoplastic lesions.

Authors:  C R Madden; M J Finegold; B L Slagle
Journal:  J Virol       Date:  2001-04       Impact factor: 5.103

2.  Basal transcriptional regulation of human damage-specific DNA-binding protein genes DDB1 and DDB2 by Sp1, E2F, N-myc and NF1 elements.

Authors:  Anne F Nichols; Toshiki Itoh; Francesca Zolezzi; Stephanie Hutsell; Stuart Linn
Journal:  Nucleic Acids Res       Date:  2003-01-15       Impact factor: 16.971

Review 3.  Functional regulation of immunoproteasomes and transporter associated with antigen processing.

Authors:  L Y Hwang; P T Lieu; P A Peterson; Y Yang
Journal:  Immunol Res       Date:  2001       Impact factor: 2.829

4.  Altered proteolysis and global gene expression in hepatitis B virus X transgenic mouse liver.

Authors:  Zongyi Hu; Zhensheng Zhang; Jin Woo Kim; Ying Huang; T Jake Liang
Journal:  J Virol       Date:  2006-02       Impact factor: 5.103

5.  Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha.

Authors:  R Weil; H Sirma; C Giannini; D Kremsdorf; C Bessia; C Dargemont; C Bréchot; A Israël
Journal:  Mol Cell Biol       Date:  1999-09       Impact factor: 4.272

6.  Peroxiredoxin 1, a Novel HBx-Interacting Protein, Interacts with Exosome Component 5 and Negatively Regulates Hepatitis B Virus (HBV) Propagation through Degradation of HBV RNA.

Authors:  Lin Deng; Xiang Gan; Masahiko Ito; Ming Chen; Hussein H Aly; Chieko Matsui; Takayuki Abe; Koichi Watashi; Takaji Wakita; Tetsuro Suzuki; Toru Okamoto; Yoshiharu Matsuura; Masashi Mizokami; Ikuo Shoji; Hak Hotta
Journal:  J Virol       Date:  2019-03-05       Impact factor: 5.103

7.  X-deficient woodchuck hepatitis virus mutants behave like attenuated viruses and induce protective immunity in vivo.

Authors:  Z Zhang; N Torii; Z Hu; J Jacob; T J Liang
Journal:  J Clin Invest       Date:  2001-11       Impact factor: 14.808

8.  Methyltransferase PRMT1 is a binding partner of HBx and a negative regulator of hepatitis B virus transcription.

Authors:  Shirine Benhenda; Aurélie Ducroux; Lise Rivière; Bijan Sobhian; Michael D Ward; Sarah Dion; Olivier Hantz; Ulrike Protzer; Marie-Louise Michel; Monsef Benkirane; Oliver J Semmes; Marie-Annick Buendia; Christine Neuveut
Journal:  J Virol       Date:  2013-02-06       Impact factor: 5.103

9.  Inhibition of cellular proteasome activities enhances hepadnavirus replication in an HBX-dependent manner.

Authors:  Zhensheng Zhang; Ulrike Protzer; Zongyi Hu; James Jacob; T Jake Liang
Journal:  J Virol       Date:  2004-05       Impact factor: 5.103

Review 10.  Hepatitis B Virus X and Regulation of Viral Gene Expression.

Authors:  Betty L Slagle; Michael J Bouchard
Journal:  Cold Spring Harb Perspect Med       Date:  2016-01-08       Impact factor: 6.915
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