Literature DB >> 26747833

Hepatitis B Virus X and Regulation of Viral Gene Expression.

Betty L Slagle1, Michael J Bouchard2.   

Abstract

The efficient replication of hepatitis B virus (HBV) requires the HBV regulatory hepatitis B virus X (HBx) protein. The exact contributions of HBx are not fully understood, in part because of the limitations of the assays used for its study. When HBV replication is driven from a plasmid DNA, the contribution of HBx is modest. However, there is an absolute requirement for HBx in assays that recapitulate the infectious virus life cycle. There is much evidence that HBx can contribute directly to HBV replication by acting on viral promoters embedded within protein coding sequences. In addition, HBx may also contribute indirectly by modulating cellular pathways to benefit virus replication. Understanding the mechanism(s) of HBx action during virus replication may provide insight into novel ways to disrupt chronic HBV replication.
Copyright © 2016 Cold Spring Harbor Laboratory Press; all rights reserved.

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Year:  2016        PMID： 26747833      PMCID： PMC4772081          DOI： 10.1101/cshperspect.a021402

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Med        ISSN： 2157-1422            Impact factor:   6.915


  163 in total

1.  The hepatitis B virus-X protein activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade.

Authors:  Y I Lee; S Kang-Park; S I Do; Y I Lee
Journal:  J Biol Chem       Date:  2001-03-01       Impact factor: 5.157

Review 2.  Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.

Authors:  Jason L Dehart; Vicente Planelles
Journal:  J Virol       Date:  2007-09-12       Impact factor: 5.103

3.  Hepatitis B virus X protein induces cell death by causing loss of mitochondrial membrane potential.

Authors:  Yumiko Shirakata; Katsuro Koike
Journal:  J Biol Chem       Date:  2003-04-03       Impact factor: 5.157

4.  Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein.

Authors:  In Young Park; Bo Hwa Sohn; Eunsil Yu; Dong Jin Suh; Young-Hwa Chung; Je-Ho Lee; Stefan J Surzycki; Young Ik Lee
Journal:  Gastroenterology       Date:  2007-01-25       Impact factor: 22.682

5.  X-gene product of hepatitis B virus induces apoptosis in liver cells.

Authors:  H Kim; H Lee; Y Yun
Journal:  J Biol Chem       Date:  1998-01-02       Impact factor: 5.157

6.  The C-terminal region of the hepatitis B virus X protein is essential for its stability and function.

Authors:  Rebecca A Lizzano; Bei Yang; Amy J Clippinger; Michael J Bouchard
Journal:  Virus Res       Date:  2010-10-20       Impact factor: 3.303

7.  Enhancement of hepatitis B virus replication by its X protein in transgenic mice.

Authors:  Zhenming Xu; T S Benedict Yen; Lanying Wu; Charles R Madden; Wenjie Tan; Betty L Slagle; Jing-hsiung Ou
Journal:  J Virol       Date:  2002-03       Impact factor: 5.103

8.  Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal.

Authors:  Kyun-Hwan Kim; Baik L Seong
Journal:  EMBO J       Date:  2003-05-01       Impact factor: 11.598

9.  Hepatitis B virus X protein interacts with a probable cellular DNA repair protein.

Authors:  T H Lee; S J Elledge; J S Butel
Journal:  J Virol       Date:  1995-02       Impact factor: 5.103

10.  Interaction of hepatitis B viral X protein and CCAAT/ enhancer-binding protein alpha synergistically activates the hepatitis B viral enhancer II/pregenomic promoter.

Authors:  B H Choi; G T Park; H M Rho
Journal:  J Biol Chem       Date:  1999-01-29       Impact factor: 5.157
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  44 in total

1.  Hepatitis B virus X protein crosses out Smc5/6 complex to maintain covalently closed circular DNA transcription.

Authors:  Bidisha Mitra; Haitao Guo
Journal:  Hepatology       Date:  2016-10-28       Impact factor: 17.425

2.  Parvulin 14 and Parvulin 17 Bind to HBx and cccDNA and Upregulate Hepatitis B Virus Replication from cccDNA to Virion in an HBx-Dependent Manner.

Authors:  Umar Saeed; Jumi Kim; Zahra Zahid Piracha; Hyeonjoong Kwon; Jaesung Jung; Yong-Joon Chwae; Sun Park; Ho-Joon Shin; Kyongmin Kim
Journal:  J Virol       Date:  2019-03-05       Impact factor: 5.103

Review 3.  Hepatitis B virus cccDNA: Formation, regulation and therapeutic potential.

Authors:  Yuchen Xia; Haitao Guo
Journal:  Antiviral Res       Date:  2020-05-22       Impact factor: 5.970

4.  HDM2 Promotes NEDDylation of Hepatitis B Virus HBx To Enhance Its Stability and Function.

Authors:  Ningning Liu; Jinfang Zhang; Xiaohai Yang; Tong Jiao; Xin Zhao; Wenxia Li; Jianhua Zhu; Pu Yang; Jianping Jin; Jirun Peng; Zhiwei Li; Xin Ye
Journal:  J Virol       Date:  2017-07-27       Impact factor: 5.103

5.  Farnesoid X receptor ablation sensitizes mice to hepatitis b virus X protein-induced hepatocarcinogenesis.

Authors:  Yongdong Niu; Meishu Xu; Betty L Slagle; Haihua Huang; Song Li; Grace L Guo; Ganggang Shi; Wenxin Qin; Wen Xie
Journal:  Hepatology       Date:  2017-01-19       Impact factor: 17.425

6.  DDB1 Stimulates Viral Transcription of Hepatitis B Virus via HBx-Independent Mechanisms.

Authors:  Woohyun Kim; Sooyoung Lee; Yeongnam Son; Chunkyu Ko; Wang-Shick Ryu
Journal:  J Virol       Date:  2016-10-14       Impact factor: 5.103

Review 7.  Hepatitis B virus: virology, molecular biology, life cycle and intrahepatic spread.

Authors:  P Karayiannis
Journal:  Hepatol Int       Date:  2017-11-02       Impact factor: 6.047

8.  Functional characterization of hepatitis B virus core promoter mutants revealed transcriptional interference among co-terminal viral mRNAs.

Authors:  Chaoyang Chen; Haodi Jia; Fei Zhang; Yanli Qin; Li Zong; Quan Yuan; Yongxiang Wang; Ningshao Xia; Jisu Li; Yumei Wen; Shuping Tong
Journal:  J Gen Virol       Date:  2016-08-23       Impact factor: 3.891

Review 9.  Role of HBx in hepatitis B virus persistence and its therapeutic implications.

Authors:  Betty L Slagle; Michael J Bouchard
Journal:  Curr Opin Virol       Date:  2018-02-20       Impact factor: 7.090

10.  Targeting Hepatitis B Virus Covalently Closed Circular DNA and Hepatitis B Virus X Protein: Recent Advances and New Approaches.

Authors:  Nicholas A Prescott; Yaron Bram; Robert E Schwartz; Yael David
Journal:  ACS Infect Dis       Date:  2019-09-27       Impact factor: 5.084
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