Literature DB >> 9207086

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells.

J M de Murcia1, C Niedergang, C Trucco, M Ricoul, B Dutrillaux, M Mark, F J Oliver, M Masson, A Dierich, M LeMeur, C Walztinger, P Chambon, G de Murcia.   

Abstract

Poly(ADP-ribose) polymerase [PARP; NAD+ ADP-ribosyltransferase; NAD+: poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyltransferase, EC 2.4.2.30] is a zinc-finger DNA-binding protein that detects specifically DNA strand breaks generated by genotoxic agents. To determine its biological function, we have inactivated both alleles by gene targeting in mice. Treatment of PARP-/- mice either by the alkylating agent N-methyl-N-nitrosourea (MNU) or by gamma-irradiation revealed an extreme sensitivity and a high genomic instability to both agents. Following whole body gamma-irradiation (8 Gy) mutant mice died rapidly from acute radiation toxicity to the small intestine. Mice-derived PARP-/- cells displayed a high sensitivity to MNU exposure: a G2/M arrest in mouse embryonic fibroblasts and a rapid apoptotic response and a p53 accumulation were observed in splenocytes. Altogether these results demonstrate that PARP is a survival factor playing an essential and positive role during DNA damage recovery.

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Year:  1997        PMID： 9207086      PMCID： PMC23816          DOI： 10.1073/pnas.94.14.7303

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

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Authors:  A Ruf; J Mennissier de Murcia; G de Murcia; G E Schulz
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-23       Impact factor: 11.205

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Authors:  T Lufkin; A Dierich; M LeMeur; M Mark; P Chambon
Journal:  Cell       Date:  1991-09-20       Impact factor: 41.582

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Journal:  Biochem Biophys Res Commun       Date:  1980-12-31       Impact factor: 3.575

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Journal:  J Biol Chem       Date:  1990-11-05       Impact factor: 5.157

6.  Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA.

Authors:  J Ménissier-de Murcia; M Molinete; G Gradwohl; F Simonin; G de Murcia
Journal:  J Mol Biol       Date:  1989-11-05       Impact factor: 5.469

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Authors:  M Ricoul; B Dutrillaux
Journal:  Mutat Res       Date:  1991 Sep-Oct       Impact factor: 2.433

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Authors:  N A Berger
Journal:  Radiat Res       Date:  1985-01       Impact factor: 2.841

9.  Atm-deficient mice: a paradigm of ataxia telangiectasia.

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Journal:  Cell       Date:  1996-07-12       Impact factor: 41.582

10.  scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.

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Journal:  Proc Natl Acad Sci U S A       Date:  1991-02-15       Impact factor: 11.205
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  323 in total

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Journal:  Biochem J       Date:  1999-10-01       Impact factor: 3.857

Review 2.  Poly(ADP-ribosylation) and apoptosis.

Authors:  A I Scovassi; G G Poirier
Journal:  Mol Cell Biochem       Date:  1999-09       Impact factor: 3.396

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Authors:  F J Oliver; J Menissier-de Murcia; G de Murcia
Journal:  Am J Hum Genet       Date:  1999-05       Impact factor: 11.025

4.  A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage.

Authors:  S Vispe; T M Yung; J Ritchot; H Serizawa; M S Satoh
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-29       Impact factor: 11.205

5.  DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression.

Authors:  W M Tong; M P Hande; P M Lansdorp; Z Q Wang
Journal:  Mol Cell Biol       Date:  2001-06       Impact factor: 4.272

6.  Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1.

Authors:  M D Vodenicharov; F R Sallmann; M S Satoh; G G Poirier
Journal:  Nucleic Acids Res       Date:  2000-10-15       Impact factor: 16.971

7.  Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair.

Authors:  Dana A Löser; Atsushi Shibata; Akiko K Shibata; Lisa J Woodbine; Penny A Jeggo; Anthony J Chalmers
Journal:  Mol Cancer Ther       Date:  2010-06-08       Impact factor: 6.261

8.  The role of DNA polymerase beta in determining sensitivity to ionizing radiation in human tumor cells.

Authors:  Conchita Vens; Els Dahmen-Mooren; Manon Verwijs-Janssen; Wim Blyweert; Lise Graversen; Harry Bartelink; Adrian C Begg
Journal:  Nucleic Acids Res       Date:  2002-07-01       Impact factor: 16.971

9.  Identification of modulated genes by three classes of chemopreventive agents at preneoplastic stages in a p53-null mouse mammary tumor model.

Authors:  Martín C Abba; Yuhui Hu; Carla C Levy; Sally Gaddis; Frances S Kittrell; Jamal Hill; Reid P Bissonnette; Powel H Brown; Daniel Medina; C Marcelo Aldaz
Journal:  Cancer Prev Res (Phila)       Date:  2009-01-27

10.  Involvement of poly(ADP-Ribose) polymerase 1 and poly(ADP-Ribosyl)ation in regulation of centrosome function.

Authors:  Masayuki Kanai; Wei-Min Tong; Eiji Sugihara; Zhao-Qi Wang; Kenji Fukasawa; Masanao Miwa
Journal:  Mol Cell Biol       Date:  2003-04       Impact factor: 4.272
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