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Literature DB >> 10544961

Poly(ADP-ribosylation) and apoptosis.

Abstract

Poly(ADP-ribosylation) is a post-translational modification playing a relevant role in DNA damage recovery, DNA replication and viral integration. Several reports also suggest a modulation of this process during cell death by apoptosis. The aim of this review is to discuss the possible involvement of poly(ADP-ribosylation) during apoptosis, by dealing with general considerations on apoptosis, and further examining the correlation between NAD consumption and cell death, the regulation of poly(ADP-ribose) metabolism in apoptotic cells, the effect of poly(ADP-ribose) polymerase inhibition on cell death occurrence and the use of enzyme cleavage as a marker of apoptosis. Finally, the future prospects of the research in this area will be addressed.

Entities: Chemical Gene

Mesh：

Substances：

Year: 1999 PMID： 10544961 DOI： 10.1023/a:1006962716377

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

127 in total

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Journal: Carcinogenesis Date: 1993-12 Impact factor: 4.944

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Authors: W Lin; J C Amé; N Aboul-Ela; E L Jacobson; M K Jacobson
Journal: J Biol Chem Date: 1997-05-02 Impact factor: 5.157

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Journal: Exp Cell Res Date: 1994-06 Impact factor: 3.905

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Authors: Z Q Wang; B Auer; L Stingl; H Berghammer; D Haidacher; M Schweiger; E F Wagner
Journal: Genes Dev Date: 1995-03-01 Impact factor: 11.361

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Authors: J Yuan; S Shaham; S Ledoux; H M Ellis; H R Horvitz
Journal: Cell Date: 1993-11-19 Impact factor: 41.582

10. Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells.

Authors: B Heller; Z Q Wang; E F Wagner; J Radons; A Bürkle; K Fehsel; V Burkart; H Kolb
Journal: J Biol Chem Date: 1995-05-12 Impact factor: 5.157

32 in total

1. Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats.

Authors: Alberto Chiarugi
Journal: Br J Pharmacol Date: 2002-11 Impact factor: 8.739

2. Helicobacter pylori VacA induces programmed necrosis in gastric epithelial cells.

Authors: Jana N Radin; Christian González-Rivera; Susan E Ivie; Mark S McClain; Timothy L Cover
Journal: Infect Immun Date: 2011-04-11 Impact factor: 3.441

3. Label-Free Quantitative Proteomic Reveals Differentially Expressed Proteins in Aeromonas-Immunostimulated Leukocytes of Lampetra japonica.

Authors: Yingying Li; Wenying Zhang; Yu Zuo; Ting Zhu; Yue Pang; Tiesong Li; Qingwei Li
Journal: Curr Microbiol Date: 2018-03-14 Impact factor: 2.188

10. Depletion of intrinsic expression of Interleukin-8 in prostate cancer cells causes cell cycle arrest, spontaneous apoptosis and increases the efficacy of chemotherapeutic drugs.

Authors: Rajendra K Singh; Bal L Lokeshwar
Journal: Mol Cancer Date: 2009-07-31 Impact factor: 27.401